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Cell Lines

MCF7 ZsGreen-ZNF703 Lenti-control Cell Line

Invented by Carlos Caldas
Invented at University of Cambridge
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Image thumbnail for MCF7 ZsGreen-ZNF703 Lenti-control Cell Line
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ZNF703‐amplified tumours are characterized by a lipid metabolism and detoxification gene expression signature and have poor clinical prognosis. Taken from Holland et al. 2011. EMBO Mol Med. 3(3):167-80. PMID: 21337521.
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Image thumbnail for MCF7 ZsGreen-ZNF703 Lenti-control Cell Line
Catalogue Number 157971
Antigen/Gene or Protein Targets Negative control for Zinc Finger Protein 703 (ZNF703) (UniProt ID: Q9H7S9)
Parental Line MCF7
Host Human
Tissue Breast
Disease Keywords Cancer
Model Tumour line
Relevance The MCF7 breast cancer human cell line infected with a control lentivirus (lenti-control) with no gene of interest. ZNF703 drives the exprsesion of the green fluorescent protein ZsGreen.

This cell line serves as the negative control for the the MCF7-ZsGreen-ZNF703 overexpressing cell line (see Related tab).
Conditional No
Research Area Cancer
Notes The pHIV-Zsgreen plasmid was cloned by removing the U6-TATAlox-CMVie-EGFP-TATAlox-WPRE content of the pSICO plasmid
(Ventura et al., 2004). ZsGreen is used as a reporter for ZNF703.

References

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References: 1 entry

Holland et al. 2011. EMBO Mol Med. 3(3):167-80. PMID: 21337521.

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References: 1 entry

Holland et al. 2011. EMBO Mol Med. 3(3):167-80. PMID: 21337521.

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