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CCSP C5 Human Ovarian Cancer subpopulation cell line

Invented by Professor Karl Skorecki, at Rambam Health Care Campus Ehood Katz, at Rambam Health Care Campus Maty Tzukerman at Rambam Health Care Campus

Info

Catalogue Number 157958
Synonyms CCSP
Host Human
Tissue Ovary
Disease Keywords Ovarian Cancer
Model Tumour line
Relevance The CCSP family of six cell lines aims to recapitulate the ovarian cancer microenvironment, and is suitable for investigation into cancer biology and cancer therapeutics research. These lines are derived from malignant ascites; a common destination for malignant ovarian cancer cells.

They have been validated in direct human-to-mouse xenografts (SCID/beige mouse muscle) and human embryonic stem cell models. The CCSP lines demonstrate morphological hallmarks of ovarian cancer and are positive for clinically relevant ovarian cancer biomarkers CA-125, CA-19.9, and MUC1, as well as the epithelial-specific antigen Ber-EP4. Tumourigenicity has been confirmed for all CCSP sub-populations in the human embryonic stem cell model, and specific sub-populations in the mouse xenograft model.
Research Area Cancer

References

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References: 1 entry

Katz et al. 2009. Clin Cancer Res. 15(1):70-80. PMID: 19118034.


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References: 1 entry

Katz et al. 2009. Clin Cancer Res. 15(1):70-80. PMID: 19118034.


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Inventor Information

Inventors

Professor Karl Skorecki

Professor Karl Skorecki

Ehood Katz

Ehood Katz

Maty Tzukerman

Maty Tzukerman

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