Anti-CLEC16A [7A4] monoclonal antibody

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References (1)

Inventor Info

Info

Catalogue Number	157892
Applications	ELISA FACS IF WB
Antigen/Gene or Protein Targets	C-Type Lectin Domain Containing 16A
Synonyms	CLEC16A (also known as KIAA0350)
Reactivity	Human
Relevance	antibody against CLEC16A (specifically binds to C-terminal human peptide CLEC16A954-980: VIVNETEADSKPSKNVARSAAVETASL) CLEC16A is a cytosolic protein which is differentially expressed in human immune cells and is known to be highly expressed on B-lymphocytes, natural killer (NK) and dendritic cells. CLEC16A gene has been linked to several autoimmune diseases, including Addison's disease, diabetes melllitus, Crohn's disease, primary biliary cirrhosis, juvenile idiopathic arthritis, rheumatoid arthritis and multiple sclerosis. . CLEC16A has been shown to regulate various immune pathways including directly regulating leukocyte antigen class II pathway in antigen presenting cells, autophagy, mitophagy, and NK cell cytotoxicity.
Host	Rat
Immunogen	27-mer C-terminal human peptide (CLEC16A 954-980: VIVNETEADSKPSKNVARSAAVETASL) linked to KLH
Positive Control	IgG2b
Research Area	Autoimmunity, Diabetes, Immunology, Neurobiology

There are 1 reference entries for this reagent.

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van Luijn et al. 2015. Brain. 138(Pt 6):1531-47. PMID: 25823473.

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van Luijn et al. 2015. Brain. 138(Pt 6):1531-47. PMID: 25823473.

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	The University of British Columbia
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