- Datasheet
- References (4)
- Inventor Info
Info
| Catalogue Number | 157879 |
| Applications | IF WB |
| Antigen/Gene or Protein Targets | EEA1 (Early endosome antigen) |
| Synonyms | MST105; MSTP105; ZFYVE2; early endosome antigen 1; early endosome antigen 1, 162kD; early endosome-associated protein; Endosome-associated protein p162; MSTP105; ZFYVE2; ZFYVE2MST105; Zinc finger FYVE domain-containing protein 2 |
| Reactivity | Human and Rabbit |
| Relevance |
Endosomes are cytoplasmic membrane-bound vesicles that function in the sorting and delivery of internalized material from the cell surface and the transport of materials from the golgi. Formed via endocytosis, endosomes can be classified by their gross morphology: early endosomes are composed of dynamic tubules whereas late endosomes are spherical with multiple internal vesicles. In neurons, early endosomes are involved in recycling of synaptic vesicles and neurotransmitter receptors. Early endosome antigen 1 (EEA1), a peripheral membrane protein associated with the cytoplasmic face of early endosomes, controls vesicle fusion during endocytosis. EEA1 is involved in neuronal synaptic vesicle function and axonal transport and growth. Autoantibodies directed against the 160 kDa EEA1 protein are seen in patients diagnosed with neurological and autoimmune conditions |
| Host | Mouse |
| Immunogen | Recombinant protein |
| Positive Control | IgG1 |
| Subclass Notes | rat brain |
| Molecular Weight (kDa) | 162 |
| Notes | Anti-EEA1 is used is useful to studied the subcellular distribution of EEA1 in neurons and the effect on neurotransmission of purified immunoglobulins from the serum samples bearing EEA1 autoantibodies. |
| Research Area | Cellular Transport |
References: 4 entries
Selak et al. 2006. Neuroscience. 143(4):953-64. PMID: 17113235.
Selak et al. 2004. Biochem Biophys Res Commun. 323(4):1334-42. PMID: 15451443.
Selak et al. 2004. BMC Neurosci. 5:2. PMID: 14728723.
Selak et al. 2003. Clin Immunol. 109(2):154-64. PMID: 14597214.
Add a reference
References: 4 entries
Selak et al. 2006. Neuroscience. 143(4):953-64. PMID: 17113235.
Selak et al. 2004. Biochem Biophys Res Commun. 323(4):1334-42. PMID: 15451443.
Selak et al. 2004. BMC Neurosci. 5:2. PMID: 14728723.
Selak et al. 2003. Clin Immunol. 109(2):154-64. PMID: 14597214.
Add a reference
Inventor Information
Inventors
|
Martin Fritzler |
