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Anti-EEA1 [1G11] monoclonal antibody
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Invented by Martin Fritzler at University Of Calgary

Info

Catalogue Number 157879
Applications IF WB
Antigen/Gene or Protein Targets EEA1 (Early endosome antigen)
Synonyms MST105; MSTP105; ZFYVE2; early endosome antigen 1; early endosome antigen 1, 162kD; early endosome-associated protein; Endosome-associated protein p162; MSTP105; ZFYVE2; ZFYVE2MST105; Zinc finger FYVE domain-containing protein 2
Reactivity Human and Rabbit
Relevance Endosomes are cytoplasmic membrane-bound vesicles that function in the sorting and delivery of internalized material from the cell surface and the transport of materials from the golgi. Formed via endocytosis, endosomes can be classified by their gross morphology: early endosomes are composed of dynamic tubules whereas late endosomes are spherical with multiple internal vesicles. In neurons, early endosomes are involved in recycling of synaptic vesicles and neurotransmitter receptors.

Early endosome antigen 1 (EEA1), a peripheral membrane protein associated with the cytoplasmic face of early endosomes, controls vesicle fusion during endocytosis. EEA1 is involved in neuronal synaptic vesicle function and axonal transport and growth. Autoantibodies directed against the 160 kDa EEA1 protein are seen in patients diagnosed with neurological and autoimmune conditions
Host Mouse
Immunogen Recombinant protein
Positive Control IgG1
Subclass Notes rat brain
Molecular Weight (kDa) 162
Notes Anti-EEA1 is used is useful to studied the subcellular distribution of EEA1 in neurons and the effect on neurotransmission of purified immunoglobulins from the serum samples bearing EEA1 autoantibodies.
Research Area Cellular Transport

References

There are 4 reference entries for this reagent.

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References: 4 entries

Selak et al. 2006. Neuroscience. 143(4):953-64. PMID: 17113235.

Selak et al. 2004. Biochem Biophys Res Commun. 323(4):1334-42. PMID: 15451443.

Selak et al. 2004. BMC Neurosci. 5:2. PMID: 14728723.

Selak et al. 2003. Clin Immunol. 109(2):154-64. PMID: 14597214.


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References: 4 entries

Selak et al. 2006. Neuroscience. 143(4):953-64. PMID: 17113235.

Selak et al. 2004. Biochem Biophys Res Commun. 323(4):1334-42. PMID: 15451443.

Selak et al. 2004. BMC Neurosci. 5:2. PMID: 14728723.

Selak et al. 2003. Clin Immunol. 109(2):154-64. PMID: 14597214.


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Inventor Information