Anti-DNA [m202-54] monoclonal antibody
Invented by Dr. Tony Marion
Invented at The University of Tennessee Health Science Center
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- References (3)
- Inventor Info
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| Catalogue Number | 157835 |
| Applications | ELISA |
| Antigen/Gene or Protein Targets | ssDNA and/or dsDNA |
| Relevance | Monoclonal anti-DNA antibodies were generated from a spontaneous mouse model of Systemic Lupus Erythematosus (SLE) (NZB x NZW)F1 using standard methodologies for the generation of B-cell hybridomas. The mice spontaneously developed anti-DNA antibodies that contributed to SLE disease. The mice were neither immunized nor stimulated non-specifically. Hybridomas derived from these autoimmune mice provide the opportunity to analyse the structure, function, and biology of autoantibodies important to understanding their contribution to the pathogenesis of SLE. Table 1 provides a summary of the variable region structures and DNA specificity for the monoclonal anti-DNA autoantibodies generated. |
| Host | Mouse |
| Immunogen UniProt ID | N/A |
| Subclass | IgM |
| Research Area | Immunology |
References: 3 entries
Marion et al. 1997. Methods. 11(1):3-11. PMID: 8990083.
Tillman et al. 1992. J Exp Med. 176(3):761-79. PMID: 1512540.
Marion et al. 1982. J Immunol. 128(2):668-74. PMID: 7198664.
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References: 3 entries
Marion et al. 1997. Methods. 11(1):3-11. PMID: 8990083.
Tillman et al. 1992. J Exp Med. 176(3):761-79. PMID: 1512540.
Marion et al. 1982. J Immunol. 128(2):668-74. PMID: 7198664.
Add a reference
Inventor Information
Inventors
|
Dr. Tony Marion |
