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Monoclonal Antibodies

Anti-DNA [m17-s128] monoclonal antibody

Invented by Dr. Tony Marion
Invented at The University of Tennessee Health Science Center
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Catalogue Number 157788
Applications ELISA
Antigen/Gene or Protein Targets ssDNA and/or dsDNA
Relevance Monoclonal anti-DNA antibodies were generated from a spontaneous mouse model of Systemic Lupus Erythematosus (SLE) (NZB x NZW)F1 using standard methodologies for the generation of B-cell hybridomas. The mice spontaneously developed anti-DNA antibodies that contributed to SLE disease. The mice were neither immunized nor stimulated non-specifically. Hybridomas derived from these autoimmune mice provide the opportunity to analyse the structure, function, and biology of autoantibodies important to understanding their contribution to the pathogenesis of SLE. Table 1 provides a summary of the variable region structures and DNA specificity for the monoclonal anti-DNA autoantibodies generated.
Host Mouse
Immunogen UniProt ID N/A
Subclass IgM
Research Area Immunology

References

There are 3 reference entries for this reagent.

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References: 3 entries

Marion et al. 1997. Methods. 11(1):3-11. PMID: 8990083.

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Tillman et al. 1992. J Exp Med. 176(3):761-79. PMID: 1512540.

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Marion et al. 1982. J Immunol. 128(2):668-74. PMID: 7198664.

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References: 3 entries

Marion et al. 1997. Methods. 11(1):3-11. PMID: 8990083.

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Tillman et al. 1992. J Exp Med. 176(3):761-79. PMID: 1512540.

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Marion et al. 1982. J Immunol. 128(2):668-74. PMID: 7198664.

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Inventor Information