Cancer Research Technology
Log in Register
Menu

Anti-DNA [m17-p3] monoclonal antibody
NEW

Invented by Dr. Tony Marion at The University of Tennessee Health Science Center

Info

Catalogue Number 157786
Applications ELISA
Antigen/Gene or Protein Targets ssDNA and/or dsDNA
Relevance Monoclonal anti-DNA antibodies were generated from a spontaneous mouse model of Systemic Lupus Erythematosus (SLE) (NZB x NZW)F1 using standard methodologies for the generation of B-cell hybridomas. The mice spontaneously developed anti-DNA antibodies that contributed to SLE disease. The mice were neither immunized nor stimulated non-specifically. Hybridomas derived from these autoimmune mice provide the opportunity to analyse the structure, function, and biology of autoantibodies important to understanding their contribution to the pathogenesis of SLE. Table 1 provides a summary of the variable region structures and DNA specificity for the monoclonal anti-DNA autoantibodies generated.
Host Mouse
Immunogen UniProt ID N/A
Subclass IgM
Research Area Immunology

References

There are 3 reference entries for this reagent.

View All References

References: 3 entries

Marion et al. 1997. Methods. 11(1):3-11. PMID: 8990083.

Tillman et al. 1992. J Exp Med. 176(3):761-79. PMID: 1512540.

Marion et al. 1982. J Immunol. 128(2):668-74. PMID: 7198664.


Add a reference

References: 3 entries

Marion et al. 1997. Methods. 11(1):3-11. PMID: 8990083.

Tillman et al. 1992. J Exp Med. 176(3):761-79. PMID: 1512540.

Marion et al. 1982. J Immunol. 128(2):668-74. PMID: 7198664.


Add a reference