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RMA.Trh4 cells

Invented by Thorbald Van Hall at Leiden University Medical Center, Stichting Oncode Institute

Info

Catalogue Number 157676
Antigen/Gene or Protein Targets Trh4
Parental Line RMA
Host Mouse
Tissue Lymphatic Tissue
Disease Keywords Mouse Leukemia
Model Tumour line
Relevance This cell line provides a model to help to understand T-cell recognition through Trh4 expression. ER-resident ceramide synthase Trh4 is a prototypic example of a neo‚Äźantigen selectively presented by cells through various pathways. RMA cells have their TAP chain intact and the Trh4 peptide is only presented on cells with impaired TAP function through the classical MHC I pathway. This cell line over-expresses endogenous Trh4 and provides a key tool to help understand presentation of Trh4 to antigen recognition though other pathways.
Research Area Cancer
Recommended Growing Conditions Retroviral transduction of the mouse Trh4 gene in an IRES-GFP construct
Positive Control RMA-S.Trh4 cells
Cellosaurus ID CVCL_J385

References

There are 1 reference entries for this reagent.

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References: 1 entry

Oliveira et al. 2011. Eur J Immunol. 41(11):3114-24. PMID: 21898382.


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References: 1 entry

Oliveira et al. 2011. Eur J Immunol. 41(11):3114-24. PMID: 21898382.


Add a reference