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RMA-S.Trh4 cells
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Invented by Thorbald Van Hall at Leiden University Medical Center, Stichting Oncode Institute

Info

Catalogue Number 157675
Antigen/Gene or Protein Targets Trh4
Parental Line RMA-S
Host Mouse
Tissue Lymphatic Tissue
Disease Keywords Mouse Leukemia
Model Tumour line
Relevance This cell line provides a model to help to understand T-cell recognition through Trh4 expression. ER-resident ceramide synthase Trh4 is a prototypic example of a neo‚Äźantigen selectively presented by cells through various pathways. RMA-S lymphoma cells are TAP-deficient on account of an incomplete TAP2 chain, whereas RMA cells have their TAP chain intact.The Trh4 peptide is only presented on cells with impaired TAP function through the classical MHC I pathway. This cell line presents said Trh4 and helps to characterise this pathway.
Production Details Retroviral transduction of the mouse Trh4 gene in an IRES-GFP construct
Research Area Cancer
Positive Control RMA.Trh4 cells
Cellosaurus ID CVCL_2180

References

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References: 1 entry

Oliveira et al. 2011. Eur J Immunol. 41(11):3114-24. PMID: 21898382.


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References: 1 entry

Oliveira et al. 2011. Eur J Immunol. 41(11):3114-24. PMID: 21898382.


Add a reference