RMA-S.Trh4 cells
Invented by Thorbald Van Hall
Invented at Leiden University and Leiden University Medical Center , Stichting Oncode Institute
- Datasheet
- References (1)
- Inventor Info
Info
| Catalogue Number | 157675 |
| Antigen/Gene or Protein Targets | Trh4 |
| Parental Line | RMA-S |
| Host | Mouse |
| Tissue | Lymphatic Tissue |
| Disease Keywords | Mouse Leukemia |
| Model | Tumour line |
| Relevance | This cell line provides a model to help to understand T-cell recognition through Trh4 expression. ER-resident ceramide synthase Trh4 is a prototypic example of a neo‐antigen selectively presented by cells through various pathways. RMA-S lymphoma cells are TAP-deficient on account of an incomplete TAP2 chain, whereas RMA cells have their TAP chain intact.The Trh4 peptide is only presented on cells with impaired TAP function through the classical MHC I pathway. This cell line presents said Trh4 and helps to characterise this pathway. |
| Production Details | Retroviral transduction of the mouse Trh4 gene in an IRES-GFP construct |
| Research Area | Cancer |
| Positive Control | RMA.Trh4 cells |
| Cellosaurus ID | CVCL_2180 |
References: 1 entry
References: 1 entry
Inventor Information
Inventors
|
Thorbald Van Hall |
