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Anti-HDAC6-ZnF (178) mouse monoclonal antibody (ZnF domain-specific)
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Catalogue Number 157672
Applications ELISA IHC IP
Antigen/Gene or Protein Targets ZnF domain of human histone deacetylase 6
Synonyms anti-HDAC6-ZnF; Histone deacetylase 6; HD6
Reactivity Human
Relevance The affinity purified mouse monoclonal antibody is immunospecific for the ZnF domain of human histone deacetylase 6 (HDAC6) as determined by ELISA. Reactivity of the mAb to homologous proteins from other species has not been tested. HDAC6 belongs to the class II of the histone deacetylase family (EC 3.5.1.98). The protein of molecular mass 131 kDa consists of two catalytic domains, the serine-glutamate-rich SE14 domain and the ubiquitin-binding ZnF domain. HDAC6 shuttles between the nucleus and the cytoplasm, but its localization is predominantly cytoplasmic. The enzyme deacetylates various substrates including α-tubulin, HSP90, cortactin, histones and other proteins. Described protein plays an important role in microtubule-dependent cell motility, apoptosis, cell signaling and transcriptional regulation, protein degradation, immune response and DNA repair. HDAC6 is linked to several neuronal diseases and carcinogenesis.
Host Mouse
Immunogen human histone deacetylase 6
Immunogen UniProt ID Q9UBN7
Subclass IgG
Research Area Cell Cycle, Cell Structure and Motility, Epigenetics & Nuclear Signalling

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