|
Catalogue Number
|
157667 |
|
Applications
|
ELISA
IHC
WB
|
|
Antigen/Gene or Protein Targets
|
human glutamate carboxypeptidase II (amino acids 21-288)
|
|
Synonyms
|
Glutamate carboxypeptidase II; NAALADase; FOLH1; PSMA; Folate Hydrolase 1; N-Acetylated Alpha-Linked Acidic Dipeptidase 1; Prostate Specific Membrane Antigen; ;PSMA; GCPII
|
|
Reactivity
|
Human
|
|
Relevance
|
GCPII reveals glutamate carboxypeptidase activity that is responsible for uptake of folate by intestine, moreover, it participates on regulation of neurotransmission via hydrolysis of the neuropeptide N-acetyl-aspartyl-glutamate in central nervous system. GCPII is expressed in several tissues including prostate epithelium, kidney, small intestine and nervous system. Disregulation of GCPII activity could be connected with hyperhomocysteinemia and various neuro-pathological conditions including glutamate excitotoxicity. GCPII stays as a leading biomarker of prostate cancer due to huge upregulation of its expression in tumor tissue.
|
|
Host
|
Mouse
|
|
Immunogen
|
human GCPII extracellular domain
|
|
Immunogen UniProt ID
|
Q04609
|
|
Subclass
|
IgG1 kappa
|
|
Research Area
|
Cancer, Metabolism
|
