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Anti-PSMA (1A11) mouse monoclonal antibody

Info

Catalogue Number 157667
Applications ELISA IHC WB
Antigen/Gene or Protein Targets human glutamate carboxypeptidase II (amino acids 21-288)
Synonyms Glutamate carboxypeptidase II; NAALADase; FOLH1; PSMA; Folate Hydrolase 1; N-Acetylated Alpha-Linked Acidic Dipeptidase 1; Prostate Specific Membrane Antigen; ;PSMA; GCPII
Reactivity Human
Relevance GCPII reveals glutamate carboxypeptidase activity that is responsible for uptake of folate by intestine, moreover, it participates on regulation of neurotransmission via hydrolysis of the neuropeptide N-acetyl-aspartyl-glutamate in central nervous system. GCPII is expressed in several tissues including prostate epithelium, kidney, small intestine and nervous system. Disregulation of GCPII activity could be connected with hyperhomocysteinemia and various neuro-pathological conditions including glutamate excitotoxicity. GCPII stays as a leading biomarker of prostate cancer due to huge upregulation of its expression in tumor tissue.
Host Mouse
Immunogen human GCPII extracellular domain
Immunogen UniProt ID Q04609
Subclass IgG1 kappa
Research Area Cancer, Metabolism

References

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References: 1 entry

Nováková et al. 2017. Prostate. 77(7):749-764. PMID: 28247415.


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References: 1 entry

Nováková et al. 2017. Prostate. 77(7):749-764. PMID: 28247415.


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