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Anti-phospho Pax3 [Ser205] monoclonal antibody

Invented by Dr. Andrew Hollenbach at LSU Health New Orleans

Info

Catalogue Number 156472
Applications WB
Antigen/Gene or Protein Targets Phosphorylated Ser205 of Pax3
Reactivity Human and Mouse
Relevance Pax3 is a transcription factor important for myogenesis and when dysregulated can cause pediatric solid muscle tumor alveolar rhabdomyosarcoma (ARMS). ARMS is primarily characterized by the t(2;13)(p35;p14) chromosomal translocation, which results in the oncogenic fusion protein Pax3-FOXO1. Using these phospho-specific antibodies it was demonstrated that the pattern of Pax3 phosphorylation at serines 201, 205, and 209 changes throughout early myogenic differentiation and that this pattern is different for Pax3-FOXO1 in primary myoblasts and in several ARMS cell lines.
Host Rat
Immunogen synthetic peptide: NH2-CAPQSDEG(pS)DIDSEP-CO2
Positive Control IgG
Research Area Cancer

References

There are 3 reference entries for this reagent.

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References: 3 entries

Loupe et al. 2015. Oncogenesis. 4:e145. PMID: 25821947.

Dietz et al. 2011. Int J Biochem Cell Biol. 43(6):936-45. PMID: 21440083.

Miller et al. 2008. Protein Sci. 17(11):1979-86. PMID: 18708529.


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References: 3 entries

Loupe et al. 2015. Oncogenesis. 4:e145. PMID: 25821947.

Dietz et al. 2011. Int J Biochem Cell Biol. 43(6):936-45. PMID: 21440083.

Miller et al. 2008. Protein Sci. 17(11):1979-86. PMID: 18708529.


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Inventor Information

Inventors

Dr. Andrew  Hollenbach

Dr. Andrew Hollenbach

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