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Relevance
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Transient receptor potential vanilloid 1 (TRPV1) is a molecular sensor of pain. Its channel activity can be modulated by several mechanisms. Phosphoinositide interacting regulator of TRP (Pirt), a membrane protein, expressed specifically in the peripheral nervous system (PNS), predominantly in nociceptive (pain) neurons has been described by several experiments indicating that Pirt is a key component of the TRPV1 complex and positively regulates TRPV1 activity. To further study this signaling pathway, a rabbit polyclonal anti-Pirt antibody that recognizes the Pirt protein has been developed.
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