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Homozygous Mutant DISC1 (1302) mouse

Info

Catalogue Number 156433
Antigen/Gene or Protein Targets DISC1
Disease Keywords Schizophrenia and psychiatric illnesses
Model Mutant
Relevance This homozygous mouse strain (1302) carries mutant hDISC1 without gross developmental defects. In this strain, the expression of mutant hDISC1 is restricted to forebrain regions using TET-off system under the control of CAMKII. In addition, the expression can be suppressed by feeding the mice with doxycycline (DOX). These transgenic animals allow selective control of mutant hDISC1 expression in forebrain neurons and, herein provide a valuable research tool to study pathogenesis of schizophrenia and to conduct experimental therapeutics for the disease. This line is on a C57BL6/J background.
Mouse Genetic Background/Cross History C57BL6/J
Zygosity Homozygous
Research Area Neurobiology, Drug Discovery & Development

References

There are 2 reference entries for this reagent.

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References: 2 entries

Pogorelov et al. 2012. Neuropharmacology. 62(3):1242-51. PMID: 21315744.

Abazyan et al. 2010. Biol Psychiatry. 68(12):1172-81. PMID: 21130225.


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References: 2 entries

Pogorelov et al. 2012. Neuropharmacology. 62(3):1242-51. PMID: 21315744.

Abazyan et al. 2010. Biol Psychiatry. 68(12):1172-81. PMID: 21130225.


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