|
Catalogue Number
|
156430 |
|
Antigen/Gene or Protein Targets
|
Keap1
|
|
Disease Keywords
|
Acute Kidney Injury and Chronic Kidney Disease
|
|
Relevance
|
This model helps elucidate a novel kelch-like ECH-associated protein 1 (KEAP 1) mediated signaling pathway in renal development. The Nrf2-Keap1 pathway has an important role in both acute kidney injury (AKI) and chronic kidney disease (CKD). This pathway has a key regulatory function on many antioxidant and stress pathways, including heme oxygenase. This model has allowed for the indetification of KEAP 1 as factor involved in cyst formation and hydronephrosis during kidney development, which is advantageous for; studying kidney development as well as the role of the KEAP 1 pathway in kidney repair and regeneration.
|
|
Mouse Genetic Background/Cross History
|
Keap1F/F mice crossed with CD4-Cre mice.
|
|
Research Area
|
Drug Discovery & Development, Other
|
