Kidney epithelial cell specific Keap1-deficient (Ksp-Keap1-KO) mouse
RECENTLY UPDATED
RECENTLY UPDATED
Invented at Johns Hopkins University
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Info
| Catalogue Number | 156430 |
| Antigen/Gene or Protein Targets | Keap1 |
| Disease Keywords | Acute Kidney Injury and Chronic Kidney Disease |
| Relevance | This model helps elucidate a novel kelch-like ECH-associated protein 1 (KEAP 1) mediated signaling pathway in renal development. The Nrf2-Keap1 pathway has an important role in both acute kidney injury (AKI) and chronic kidney disease (CKD). This pathway has a key regulatory function on many antioxidant and stress pathways, including heme oxygenase. This model has allowed for the indetification of KEAP 1 as factor involved in cyst formation and hydronephrosis during kidney development, which is advantageous for; studying kidney development as well as the role of the KEAP 1 pathway in kidney repair and regeneration. |
| Mouse Genetic Background/Cross History | Keap1F/F mice crossed with CD4-Cre mice. |
| Research Area | Drug Discovery & Development, Other |
