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Kidney epithelial cell specific Keap1-deficient (Ksp-Keap1-KO) mouse

Info

Catalogue Number 156430
Antigen/Gene or Protein Targets Keap1
Disease Keywords Acute Kidney Injury and Chronic Kidney Disease
Relevance This model helps elucidate a novel kelch-like ECH-associated protein 1 (KEAP 1) mediated signaling pathway in renal development. The Nrf2-Keap1 pathway has an important role in both acute kidney injury (AKI) and chronic kidney disease (CKD). This pathway has a key regulatory function on many antioxidant and stress pathways, including heme oxygenase. This model has allowed for the indetification of KEAP 1 as factor involved in cyst formation and hydronephrosis during kidney development, which is advantageous for; studying kidney development as well as the role of the KEAP 1 pathway in kidney repair and regeneration.
Mouse Genetic Background/Cross History Keap1F/F mice crossed with CD4-Cre mice.
Research Area Drug Discovery & Development, Other

References

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References: 1 entry

Noel et al. 2015. J Am Soc Nephrol. 26(12):2989-3000. PMID: 26293820.


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References: 1 entry

Noel et al. 2015. J Am Soc Nephrol. 26(12):2989-3000. PMID: 26293820.


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