R-3327-MAT-Lu cell line
Invented at Johns Hopkins University
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- References (2)
- Inventor Info
Info
| Catalogue Number | 156409 |
| Antigen/Gene or Protein Targets | Metastatic anaplastic tumor that is highly metastatic in the lung |
| Disease Keywords | Prostate Cancer |
| Model | Cancer Model |
| Relevance | This cell line was derived from the "H" subline and upon passage to the AT-1 subline (JHU-29) of the parental R3327 tumor. The "H" subline is a heterogeneous cell line as it is comprised of androgen-dependent and androgen-independent tumor cells. Passing this AT-1 sublinein intactmale rats allowed for the cloning of androgen-independent cell lines which gave rise to a fast-growing metastatic, anaplastic tumor (MAT) cell line which was further characterized to be highly metastatic to the lung (MAT-Lu). This cell line is a valuable model for the studying prostate malignancies both in vitro, and in vivo.DM 3852 |
| Research Area | Cancer, Drug Discovery & Development |
| Cellosaurus ID | CVCL_3847 |
References: 2 entries
Isaacs et al. 1988. Prostate. 13(2):165-88. PMID: 3174494.
Isaacs et al. 1986. Prostate. 9(3):261-81. PMID: 3774632.
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References: 2 entries
Isaacs et al. 1988. Prostate. 13(2):165-88. PMID: 3174494.
Isaacs et al. 1986. Prostate. 9(3):261-81. PMID: 3774632.
Add a reference
