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USP9x-deficient DLD-1 (with or without p53) cell line

Info

Catalogue Number 156404
Antigen/Gene or Protein Targets USP9X and p53
Parental Line DLD-1
Tissue Colon
Disease Keywords Cancer
Model Knock-Out
Relevance This cell line presents an opportunity to study the effect of loss of apoptotic control on colorectal cancer cells. Study of deubiquitinase Ups9X could act as a leap towards understanding apoptotic regulation and potentially lead to new drug targets for cancer.
In this technology, the gene USP9X is knocked out of two colorectal DLD-1 cells. The gene knockout has been performed by rAAV-mediated homologous recombination. The technology also consists of a double knockout line without USP9X and p53, a tumor suppressor gene.
Research Area Cancer, Drug Discovery & Development

References

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References: 1 entry

Harris et al. 2012. Cancer Biol Ther. 13(13):1319-24. PMID: 22895071.


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References: 1 entry

Harris et al. 2012. Cancer Biol Ther. 13(13):1319-24. PMID: 22895071.


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