Cancer Research Technology
Log in Register
Menu

USP9x-deficient HCT116 (with or without p53) cell line

Info

Catalogue Number 156403
Antigen/Gene or Protein Targets USP9X and p53
Parental Line HCT 116
Tissue Colon
Disease Keywords Cancer
Model Knock-Out
Relevance This cell line presents an opportunity to study the effect of loss of apoptotic control on colorectal cancer cells. Study of deubiquitinase Ups9X could act as a leap towards understanding apoptotic regulation and potentially lead to new drug targets for cancer.
In this technology, the gene USP9X is knocked out of two the HCT116 cell line. The gene knockout has been performed by rAAV-mediated homologous recombination. The technology also consists of a double knockout line without USP9X and p53, a tumor suppressor gene.
Research Area Cancer, Drug Discovery & Development

References

There are 1 reference entries for this reagent.

View All References

References: 1 entry

Harris et al. 2012. Cancer Biol Ther. 13(13):1319-24. PMID: 22895071.


Add a reference

References: 1 entry

Harris et al. 2012. Cancer Biol Ther. 13(13):1319-24. PMID: 22895071.


Add a reference

Inventor Information

No inventors are currently linked to this reagent.

Add an inventor