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Catalogue Number
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156375 |
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Applications
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FACS
IP
WB
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Antigen/Gene or Protein Targets
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b-Chain Associated Regulator of Apoptosis
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Synonyms
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BARA, BARPsv, Lin-9, TGS, TGS1, TGS2 or lin-9 DREAM MuvB core complex component
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Reactivity
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Rat, Human and Mouse
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Relevance
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LIN-9 regulates cell transformation and proliferation in mammalian cells by inhibiting DNA synthesis. LIN-9 is inhibited by the regulatory subunit of CDK4, cyclin D. Deletion of the first 84 amino acids of Mip/LIN-9 (Mip/LIN-9∆84) corrects the CDK4 null phenotype. Therefore, Mip/LIN-9, like the pocket proteins pRB, p107 and p130, is negatively regulated by CDK4. Moreover, the correction of the CDK4 null phenotype is accompanied by a restoration of the expression of genes such as E2F1, E2F3, and cyclin E suggesting that Mip/LIN-9 participates in the regulation of E2F target genes required for the G1/S transition.
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Host
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Mouse
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Immunogen
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full-length GST-BARA/LIN9-L fusion protein
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Positive Control
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IgG1
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Notes
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This mAb recognizes an epitope within exon 4 since it detects only the long form of the protein.
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Research Area
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Cell Cycle, Epigenetics & Nuclear Signalling
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