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Anti-BARA/LIN-9 [mAb#1] monoclonal antibody

Info

Catalogue Number 156375
Applications FACS IP WB
Antigen/Gene or Protein Targets b-Chain Associated Regulator of Apoptosis
Synonyms BARA, BARPsv, Lin-9, TGS, TGS1, TGS2 or lin-9 DREAM MuvB core complex component
Reactivity Rat, Human and Mouse
Relevance LIN-9 regulates cell transformation and proliferation in mammalian cells by inhibiting DNA synthesis. LIN-9 is inhibited by the regulatory subunit of CDK4, cyclin D. Deletion of the first 84 amino acids of Mip/LIN-9 (Mip/LIN-9∆84) corrects the CDK4 null phenotype. Therefore, Mip/LIN-9, like the pocket proteins pRB, p107 and p130, is negatively regulated by CDK4. Moreover, the correction of the CDK4 null phenotype is accompanied by a restoration of the expression of genes such as E2F1, E2F3, and cyclin E suggesting that Mip/LIN-9 participates in the regulation of E2F target genes required for the G1/S transition.
Host Mouse
Immunogen full-length GST-BARA/LIN9-L fusion protein
Positive Control IgG1
Notes This mAb recognizes an epitope within exon 4 since it detects only the long form of the protein.
Research Area Cell Cycle, Epigenetics & Nuclear Signalling

References

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References: 1 entry

Sandoval et al. 2006. Exp Cell Res. 312(13):2465-75. PMID: 16730350.


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References: 1 entry

Sandoval et al. 2006. Exp Cell Res. 312(13):2465-75. PMID: 16730350.


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