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Anti-CD-45 [C455.1F] monoclonal antibody
RECENTLY UPDATED

Info

Catalogue Number 155248
Applications N/A
Antigen/Gene or Protein Targets
RECENTLY UPDATED
CD45
Reactivity N/A
Relevance
RECENTLY UPDATED
Monoclonal antibody which binds to an epitope within exon C of CD45.

Background and Research Application
CD45RC, or PTPRC, is a protein tyrosine-protein phosphatase required for T cell activation through the antigen receptor. CD45 regulates Src-family kinases, integrin-mediated signal transduction pathways and can suppress JAK kinases, acting as a negative regulator of cytokine receptor signalling. Upon T cell activation, CD45RC recruits and dephosphorylates SKAP1 and FYN. Mutations of the gene can result in severe combined immunodeficiency and multiple sclerosis.

This antibody binds to an exon C-dependent epitope of CD45 glycoprotein.
Immunogen UniProt ID
RECENTLY UPDATED
P06800
Subclass
RECENTLY UPDATED
IgG2a kappa
Notes
RECENTLY UPDATED
Production Details
Purified using multi-step affinity chromatography with protein A.

Storage Conditions
Store at -20 degrees frozen. Avoid repeated freeze/thaw cycles.

Points of Interest
This antibody reacts with a subset of CD45 (T200) molecules by binding to a determinant requiring the expression of the second variable exon of the CD45 molecule.

Concentration
1mg/ml as standard
Research Area
RECENTLY UPDATED
Immunology

References

There are 1 reference entries for this reagent.

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References: 1 entry
RECENTLY UPDATED

Bottomly et al. 1989. Eur J Immunol. 19(4):617-23. PMID: 2567241.


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References: 1 entry
RECENTLY UPDATED

Bottomly et al. 1989. Eur J Immunol. 19(4):617-23. PMID: 2567241.


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Inventor Information

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