Anti-CD-45 [C455.1F] monoclonal antibody
Invented at Yale University
- Datasheet
- References (1)
- Inventor Info
Info
| Catalogue Number | 155248 |
| Applications | N/A |
| Antigen/Gene or Protein Targets | CD45 |
| Reactivity | N/A |
| Relevance |
Monoclonal antibody which binds to an epitope within exon C of CD45. Background and Research Application CD45RC, or PTPRC, is a protein tyrosine-protein phosphatase required for T cell activation through the antigen receptor. CD45 regulates Src-family kinases, integrin-mediated signal transduction pathways and can suppress JAK kinases, acting as a negative regulator of cytokine receptor signalling. Upon T cell activation, CD45RC recruits and dephosphorylates SKAP1 and FYN. Mutations of the gene can result in severe combined immunodeficiency and multiple sclerosis. This antibody binds to an exon C-dependent epitope of CD45 glycoprotein. |
| Immunogen UniProt ID | P06800 |
| Subclass | IgG2a kappa |
| Notes |
Production Details Purified using multi-step affinity chromatography with protein A. Storage Conditions Store at -20 degrees frozen. Avoid repeated freeze/thaw cycles. Points of Interest This antibody reacts with a subset of CD45 (T200) molecules by binding to a determinant requiring the expression of the second variable exon of the CD45 molecule. Concentration 1mg/ml as standard |
| Research Area | Immunology |
