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Anti-CD3 [500.A2] monoclonal antibody
RECENTLY UPDATED

Info

Catalogue Number 155246
Applications N/A
Antigen/Gene or Protein Targets
RECENTLY UPDATED
CD3
Reactivity N/A
Relevance
RECENTLY UPDATED
Monoclonal antibody capable of activating T cells and cloned T cell lines.

Background and Research Application
The CD3 complex, composed of four distinct CD3 polypeptide chains (CD3γ, CD3δ and 2X CD3Ɛ), associates with the T cell antigen receptor (TCR. CD3 is a member of the immunoglobulin superfamily, involved in antigen recognition, T lymphocyte activation and signal transduction. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases.
This antibody activates cloned T cell lines and normal T cells, provided suitable accessory cells and signals are present. Binding of anti-CD3 (500.A2) to CD3 initiates the intracellular biochemical pathway resulting in cellular activation and proliferation.
Host
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Hamster
Immunogen
RECENTLY UPDATED
25-kDa ε chain of the T-cell receptor-associated CD3 complex
Immunogen UniProt ID
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A0A3Q0CNZ4
Subclass
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IgG
Notes
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Production Details
Purified using multi-step affinity chromatography with protein A.

Storage Conditions
Store at -20 degrees frozen. Avoid repeated freeze/thaw cycles.

Points of Interest
This antibody likely binds CD3 in a location close to a postulated binding site of CD4 to the TCR.

Concentration
1mg/ml as standard
Research Area
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Immunology

References

There are 8 reference entries for this reagent.

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References: 8 entries
RECENTLY UPDATED

Chen et al. 2019. JCI Insight. 4(22):. PMID: 31723059.

Trittel et al. 2019. Sci Rep. 9(1):16362. PMID: 31704965.

Czarnewski et al. 2019. Nat Commun. 10(1):2892. PMID: 31253778.

Zwick et al. 2019. Front Immunol. 10:222. PMID: 30809231.

Shahbaz et al. 2018. PLoS Biol. 16(12):e2006649. PMID: 30550561.

Maj et al. 2017. Nat Immunol. 18(12):1332-1341. PMID: 29083399.

Long et al. 2016. Genes (Basel). 8(1):. PMID: 28035981.

Portoles et al. 1989. J Immunol. 142(12):4169-75. PMID: 2470817.


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References: 8 entries
RECENTLY UPDATED

Chen et al. 2019. JCI Insight. 4(22):. PMID: 31723059.

Trittel et al. 2019. Sci Rep. 9(1):16362. PMID: 31704965.

Czarnewski et al. 2019. Nat Commun. 10(1):2892. PMID: 31253778.

Zwick et al. 2019. Front Immunol. 10:222. PMID: 30809231.

Shahbaz et al. 2018. PLoS Biol. 16(12):e2006649. PMID: 30550561.

Maj et al. 2017. Nat Immunol. 18(12):1332-1341. PMID: 29083399.

Long et al. 2016. Genes (Basel). 8(1):. PMID: 28035981.

Portoles et al. 1989. J Immunol. 142(12):4169-75. PMID: 2470817.


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Inventor Information

No inventors are currently linked to this reagent.

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