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Anti-IAb +Ea peptide [YAe] monoclonal antibody
RECENTLY UPDATED

Info

Catalogue Number 155244
Applications N/A
Antigen/Gene or Protein Targets
RECENTLY UPDATED
MHC Class II (IA/IE)
Reactivity N/A
Relevance
RECENTLY UPDATED
Monoclonal antibody which binds YAe antigen on B cells and antigen presenting cells.

Background and Research Application
This YAe antibody reacts with a class II major histocompatibility complex (MHC) self Ea peptide (peptide 52-68) bound to I-Ab molecules. The YAe antibody binds to an epitope expressed on a subset of class II I-Ab molecules in strains that also express class II I-Eb. This epitope is found on peripheral B cells and on cells in the thymic medulla, but not thymic cortical epithelium. In addition to B cells, the YAe antigen is expressed at comparable levels on other antigen presenting cells, including macrophages and dendritic cells. This antibody does not react with invariant chain-associated class II MHC complexes.
Immunogen UniProt ID
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P14483
Notes
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Production Details
Purified using multi-step affinity chromatography with protein A.

Storage Conditions
Store at -20 degrees frozen. Avoid repeated freeze/thaw cycles.

Points of Interest
This antibody reacts with 10-15% of surface I-Ab molecules in strains that also express surface I-Eb molecules.

Concentration
1mg/ml as standard
Research Area
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Immunology

References

There are 4 reference entries for this reagent.

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References: 4 entries
RECENTLY UPDATED

Bonacina et al. 2018. Nat Commun. 9(1):3083. PMID: 30082772.

Rouhani et al. 2015. Nat Commun. 6:6771. PMID: 25857745.

Michelet et al. 2015. J Immunol. 194(5):2079-88. PMID: 25637027.

Murphy et al. 1989. Nature. 338(6218):765-8. PMID: 2469959.


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References: 4 entries
RECENTLY UPDATED

Bonacina et al. 2018. Nat Commun. 9(1):3083. PMID: 30082772.

Rouhani et al. 2015. Nat Commun. 6:6771. PMID: 25857745.

Michelet et al. 2015. J Immunol. 194(5):2079-88. PMID: 25637027.

Murphy et al. 1989. Nature. 338(6218):765-8. PMID: 2469959.


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Inventor Information

No inventors are currently linked to this reagent.

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