Anti-IAb +Ea peptide [YAe] monoclonal antibody
Invented at Yale University
- Datasheet
- References (4)
- Inventor Info
Info
| Catalogue Number | 155244 |
| Applications | N/A |
| Antigen/Gene or Protein Targets | MHC Class II (IA/IE) |
| Reactivity | N/A |
| Relevance |
Monoclonal antibody which binds YAe antigen on B cells and antigen presenting cells. Background and Research Application This YAe antibody reacts with a class II major histocompatibility complex (MHC) self Ea peptide (peptide 52-68) bound to I-Ab molecules. The YAe antibody binds to an epitope expressed on a subset of class II I-Ab molecules in strains that also express class II I-Eb. This epitope is found on peripheral B cells and on cells in the thymic medulla, but not thymic cortical epithelium. In addition to B cells, the YAe antigen is expressed at comparable levels on other antigen presenting cells, including macrophages and dendritic cells. This antibody does not react with invariant chain-associated class II MHC complexes. |
| Immunogen UniProt ID | P14483 |
| Notes |
Production Details Purified using multi-step affinity chromatography with protein A. Storage Conditions Store at -20 degrees frozen. Avoid repeated freeze/thaw cycles. Points of Interest This antibody reacts with 10-15% of surface I-Ab molecules in strains that also express surface I-Eb molecules. Concentration 1mg/ml as standard |
| Research Area | Immunology |
References: 4 entries
Bonacina et al. 2018. Nat Commun. 9(1):3083. PMID: 30082772.
Rouhani et al. 2015. Nat Commun. 6:6771. PMID: 25857745.
Michelet et al. 2015. J Immunol. 194(5):2079-88. PMID: 25637027.
Murphy et al. 1989. Nature. 338(6218):765-8. PMID: 2469959.
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References: 4 entries
Bonacina et al. 2018. Nat Commun. 9(1):3083. PMID: 30082772.
Rouhani et al. 2015. Nat Commun. 6:6771. PMID: 25857745.
Michelet et al. 2015. J Immunol. 194(5):2079-88. PMID: 25637027.
Murphy et al. 1989. Nature. 338(6218):765-8. PMID: 2469959.
Add a reference
