Anti-heat stable antigen [20C9] monoclonal antibody
Invented at Yale University
- Datasheet
- References (3)
- Inventor Info
Info
| Catalogue Number | 155239 |
| Applications | N/A |
| Antigen/Gene or Protein Targets | Heat Stable Antigen |
| Reactivity | N/A |
| Relevance |
Monoclonal antibody with a broad spectrum of inhibitory effects on the expansion of T cells induced via TCR. Background and Research Application Signal transducer CD24 also known as cluster of differentiation 24 or heat stable antigen CD24 (HSA) is a cell adhesion molecule encoded by the CD24 gene. Anti-HSA significantly inhibits the proliferation of CD4 T cells induced by anti-CD3 or by allogeneic LPS-activated B cells. Engagement of the TCR in the presence of this monoclonal antibody leads to functional inactivation of T cells. |
| Immunogen UniProt ID | P07900 |
| Notes |
Production Details Purified using multi-step affinity chromatography with protein A. Storage Conditions Store at -20 degrees frozen. Avoid repeated freeze/thaw cycles. Points of Interest Heat stable antigen has a direct costimulatory activity for clonal expansion of normal CD4 T cells. Concentration 1mg/ml as standard |
| Research Area | Immunology |
References: 3 entries
Li et al. 2006. J Exp Med. 203(7):1713-20. PMID: 16769998.
Bai et al. 2004. J Exp Med. 200(4):447-58. PMID: 15314074.
Liu et al. 1992. J Exp Med. 175(2):437-45. PMID: 1346270.
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References: 3 entries
Li et al. 2006. J Exp Med. 203(7):1713-20. PMID: 16769998.
Bai et al. 2004. J Exp Med. 200(4):447-58. PMID: 15314074.
Liu et al. 1992. J Exp Med. 175(2):437-45. PMID: 1346270.
Add a reference
