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Anti-IE of b,k,r,s,v [Y17] monoclonal antibody
RECENTLY UPDATED

Info

Catalogue Number 155238
Applications N/A
Antigen/Gene or Protein Targets
RECENTLY UPDATED
IE
Reactivity N/A
Relevance
RECENTLY UPDATED
Monoclonal antibody which can inhibit T cell response to Ae:E alpha determinants.

Background and Research Application
This antibody is directed at a conformational or combinatorial determinant formed by certain Ae:E alpha complexes. This marker is found upon a subset of B cells as well as on non-T and non-B spleen cells.
Antibody Y-17 can inhibit the response of T cells to Ae:E alpha determinants in mixed lymphocyte cultures. Furthermore, Y-17 inhibits the antigen-induced T cell proliferative response to GLPhe and pigeon cytochrome c; responses which are under dual-Ir-gene control and correlate with the expression of certain A~:E~ complexes on antigen-presenting cell surfaces.
Immunogen UniProt ID
RECENTLY UPDATED
P04223
Subclass
RECENTLY UPDATED
IgG2b
Notes
RECENTLY UPDATED
Production Details
Purified using multi-step affinity chromatography with protein A.

Storage Conditions
Store at -20 degrees frozen. Avoid repeated freeze/thaw cycles.

Points of Interest
Besides Ae and E alpha chains, Y-17 precipitates a third chain that is indistinguishable from the A alpha chain in two-dimensional gels.

Concentration
1mg/ml as standard
Research Area
RECENTLY UPDATED
Immunology

References

There are 1 reference entries for this reagent.

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References: 1 entry
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Lerner et al. 1980. J Exp Med. 152(4):1085-101. PMID: 6158546.


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References: 1 entry
RECENTLY UPDATED

Lerner et al. 1980. J Exp Med. 152(4):1085-101. PMID: 6158546.


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Inventor Information

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