Anti-Sm [Y12] monoclonal antibody
Invented at Yale University
- Datasheet
- References (1)
- Inventor Info
Info
| Catalogue Number | 155237 |
| Applications | N/A |
| Antigen/Gene or Protein Targets | Sm |
| Reactivity | N/A |
| Relevance |
Monoclonal antibody used in quantitative radioimmuno-assays in SLE patients. Background and Research Application Sm is an autoantigen on a series of particles composed of RNA and protein. It is one of several nuclear proteins that are found commonly among U1, U2, U4/U6, and U5 small ribonucleoprotein particles (snRNPs). These snRNPs are involved in pre-mRNA splicing, and the encoded protein may also play a role in pre-mRNA splicing or snRNP structure. Sm is involved in the pathogenesis of Systemic lupus erythematosus (SLE), with antibodies to Sm being found in 20-30% of patients with SLE. This antibody can aid in the titration of autoantibody activity in the sera of SLE patients. Anti-Sm antibody can be used to help understand the role of snRNPs, particularly within disease. |
| Host | Mouse |
| Immunogen UniProt ID | P27048 |
| Subclass | IgG3 kappa |
| Notes |
Production Details Purified using multi-step affinity chromatography with protein A. Storage Conditions Store at -20 degrees frozen. Avoid repeated freeze/thaw cycles. Concentration 1mg/ml as standard |
| Research Area | Immunology |
