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Anti-IA of b,f,p,q,r,s,u,v [Y3JP] monoclonal antibody

Info

Catalogue Number 155236
Applications N/A
Antigen/Gene or Protein Targets IA b,f,p,q,r,s,u,v
Reactivity N/A
Relevance Monoclonal antibody capable of inhibiting I-A-restricted T cell responses.

Background and Research Application
The anti-IA monoclonal antibody reacts with mouse MHC Class II haplotypes I-Ab, I-Af, I-Ap, I-Aq, I-Ar, I-As, I-Au, I-Av, and weakly with I-Ak.
This antibody is reported to inhibit I-A-restricted T cell responses.
Host Mouse
Immunogen UniProt ID P11911
Subclass IgG2a
Notes Production Details
Purified using multi-step affinity chromatography with protein A.

Storage Conditions
Store at -20 degrees frozen. Avoid repeated freeze/thaw cycles.

Points of Interest
This antibody reacts with I-A subregion-controlled A alpha:A beta complexes of all mouse strains apart from the responder strain (H-2d), as well as the equivalent of A alpha:A beta complexes in rats carrying seven independent haplotypes.

Concentration
1mg/ml as standard
Research Area Immunology

References

There are 4 reference entries for this reagent.

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References: 4 entries

Campisi et al. 2016. Nat Immunol. 17(9):1084-92. PMID: 27455420.

Feng et al. 2015. Nature. 528(7580):132-136. PMID: 26605529.

Guo et al. 2015. Nat Immunol. 16(10):1051-9. PMID: 26322482.

Janeway CA et al. 1984. J Immunol. 132(2):662-7. PMID: 6228596.


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References: 4 entries

Campisi et al. 2016. Nat Immunol. 17(9):1084-92. PMID: 27455420.

Feng et al. 2015. Nature. 528(7580):132-136. PMID: 26605529.

Guo et al. 2015. Nat Immunol. 16(10):1051-9. PMID: 26322482.

Janeway CA et al. 1984. J Immunol. 132(2):662-7. PMID: 6228596.


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Inventor Information

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