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Anti-CD3 [C363.29B] monoclonal antibody
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Info

Catalogue Number 155234
Applications N/A
Antigen/Gene or Protein Targets
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CD3
Reactivity N/A
Relevance
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Monoclonal antibody which binds an epitope within the CD3-TCR complex.

Background and Research Application
The CD3 complex, composed of four distinct CD3 polypeptide chains (CD3γ, CD3δ and 2X CD3Ɛ), associates with the T cell antigen receptor (TCR. CD3 is a member of the immunoglobulin superfamily, involved in antigen recognition, T lymphocyte activation and signal transduction. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases.
This antibody reacts with an epitope located in the epsilon chain of the CD3/TCR complex.
Host
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Rat
Immunogen UniProt ID
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P07766
Notes
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Production Details
Purified using multi-step affinity chromatography with protein A.

Storage Conditions
Store at -20 degrees frozen. Avoid repeated freeze/thaw cycles.

Concentration
1mg/ml as standard
Research Area
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Immunology

References

There are 4 reference entries for this reagent.

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References: 4 entries
RECENTLY UPDATED

Mohamad et al. 2019. Nutr Metab (Lond). 16:49. PMID: 31372176.

Zulkawi et al. 2017. BMC Complement Altern Med. 17(1):344. PMID: 28666436.

Muraille et al. 2010. PLoS Pathog. 6(10):e1001154. PMID: 20976202.

Portoles et al. 1989. J Immunol. 142(12):4169-75. PMID: 2470817.


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References: 4 entries
RECENTLY UPDATED

Mohamad et al. 2019. Nutr Metab (Lond). 16:49. PMID: 31372176.

Zulkawi et al. 2017. BMC Complement Altern Med. 17(1):344. PMID: 28666436.

Muraille et al. 2010. PLoS Pathog. 6(10):e1001154. PMID: 20976202.

Portoles et al. 1989. J Immunol. 142(12):4169-75. PMID: 2470817.


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Inventor Information

No inventors are currently linked to this reagent.

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