Anti-CD3 [C363.29B] monoclonal antibody
Invented at Yale University
- Datasheet
- References (4)
- Inventor Info
Info
| Catalogue Number | 155234 |
| Applications | N/A |
| Antigen/Gene or Protein Targets | CD3 |
| Reactivity | N/A |
| Relevance |
Monoclonal antibody which binds an epitope within the CD3-TCR complex. Background and Research Application The CD3 complex, composed of four distinct CD3 polypeptide chains (CD3γ, CD3δ and 2X CD3Ɛ), associates with the T cell antigen receptor (TCR. CD3 is a member of the immunoglobulin superfamily, involved in antigen recognition, T lymphocyte activation and signal transduction. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. This antibody reacts with an epitope located in the epsilon chain of the CD3/TCR complex. |
| Host | Rat |
| Immunogen UniProt ID | P07766 |
| Notes |
Production Details Purified using multi-step affinity chromatography with protein A. Storage Conditions Store at -20 degrees frozen. Avoid repeated freeze/thaw cycles. Concentration 1mg/ml as standard |
| Research Area | Immunology |
References: 4 entries
Mohamad et al. 2019. Nutr Metab (Lond). 16:49. PMID: 31372176.
Zulkawi et al. 2017. BMC Complement Altern Med. 17(1):344. PMID: 28666436.
Muraille et al. 2010. PLoS Pathog. 6(10):e1001154. PMID: 20976202.
Portoles et al. 1989. J Immunol. 142(12):4169-75. PMID: 2470817.
Add a reference
References: 4 entries
Mohamad et al. 2019. Nutr Metab (Lond). 16:49. PMID: 31372176.
Zulkawi et al. 2017. BMC Complement Altern Med. 17(1):344. PMID: 28666436.
Muraille et al. 2010. PLoS Pathog. 6(10):e1001154. PMID: 20976202.
Portoles et al. 1989. J Immunol. 142(12):4169-75. PMID: 2470817.
Add a reference
