Anti-FANCM [CV5.1] recombinant antibody
Invented at Cancer Research UK London Research Institute: Clare Hall Laboratories
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Info
| Catalogue Number | 154823 |
| Antigen/Gene or Protein Targets | Human FANCM (Fanconi anemia, complementation group M) |
| Synonyms | Fanconi Anemia Complementation Group M; KIAA1596; Fanconi Anemia-Associated Polypeptide Of 250 Kda; ATP-Dependent RNA Helicase FANCM; Protein Hef Ortholog; FAAP250 |
| Reactivity | Human |
| Relevance |
Fanconi anemia, complementation group M. Fanconi anemia-associated polypeptide of 250 kDa. ATPase required for FANCD2 ubiquitination, a key reaction in DNA repair. Binds to ssDNA but not to dsDNA. Recruited to forks stalled by DNA interstrand cross-links, and required for cellular resistance to such lesions. |
| Host | Mouse |
| Immunogen | His-tagged denatured FANCM (aa 1507-1679) made in E.coli |
| Subclass | IgG1 kappa |
| Positive Control | 293 cell extract |
| Research Area | DNA Damage and Repair, Epigenetics & Nuclear Signalling |
| Notes |
Suggested Dilutions: WB - 1:1000, IP - 2-4ug/ml lysate, IF - 1:100 Other species were not tested but there is high sequence conservation. |
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