Anti-CD79b [B29/123] recombinant antibody
Invented at University of Oxford
- Datasheet
- References (12)
- Inventor Info
Info
| Catalogue Number | 154819 |
| Antigen/Gene or Protein Targets | CD79b |
| Synonyms | CD79b Molecule; CD79B Antigen (Immunoglobulin-Associated Beta); Immunoglobulin-Associated B29 Protein; B-Cell-Specific Glycoprotein B29; Ig-Beta |
| Reactivity | Human |
| Relevance | The B-cell Antigen receptor constitutes a disulphide linked heterodimer, consisting of CD79a (mb1) and CD79b / B29 polypeptides which are non-covalently associated with membrane bound immunoglobulins on B-cells. CD79a first appears at pre B-cell stage and persists until the plasma cell stage where it is found as an intracellular component. CD79a is found in B-cell lymphomas, in B-cell lines, the majority of acute leukemias of precursor B-cell type and in some myelomas. The CD79a/b heterodimer interacts with at least one tyrosine kinase (Lyn). The induction of tyrosine kinase activity after antigen binding leads to phosphorylation of the CD79a/b dimer, and also of other molecules, thereby initiating intracellular signalling. |
| Host | Mouse |
| Immunogen | Synthetic peptide representing the c-terminus from residue 215 of the murine B29 polypeptide. |
| Subclass | IgG2b |
| Research Area | Cell Signaling & Signal Transduction, Immunology |
References: 12 entries
A role for lysosomal-associated protein transmembrane 5 in the negative regulation of surface B cell receptor levels and B cell activation.
Broad feedback inhibition of pre-B-cell receptor signaling components.
Brouns et al. 1993. Eur J Immunol. 23(5):1088-97. PMID: 8477803.
Detection of T and B cells in many animal species using cross-reactive anti-peptide antibodies.
Evidence for a direct physical interaction of membrane IgM, IgD, and IgG with the B29 gene product.
Hauser et al. 2013. Mol Immunol. 54(3-4):247-53. PMID: 23318223.
Jones et al. 1993. J Immunol. 150(12):5429-35. PMID: 8515069.
Lankester et al. 1994. J Immunol. 152(5):2157-62. PMID: 8133032.
Mason et al. 1992. Eur J Immunol. 22(10):2753-6. PMID: 1396979.
Ouchida et al. 2010. J Immunol. 185(1):294-301. PMID: 20519653.
The B29 and mb-1 polypeptides are differentially expressed during human B cell differentiation.
The structure of the mu/pseudo light chain complex on human pre-B cells is consistent with a function in signal transduction.
Add a reference
References: 12 entries
A role for lysosomal-associated protein transmembrane 5 in the negative regulation of surface B cell receptor levels and B cell activation.
Broad feedback inhibition of pre-B-cell receptor signaling components.
Brouns et al. 1993. Eur J Immunol. 23(5):1088-97. PMID: 8477803.
Detection of T and B cells in many animal species using cross-reactive anti-peptide antibodies.
Evidence for a direct physical interaction of membrane IgM, IgD, and IgG with the B29 gene product.
Hauser et al. 2013. Mol Immunol. 54(3-4):247-53. PMID: 23318223.
Jones et al. 1993. J Immunol. 150(12):5429-35. PMID: 8515069.
Lankester et al. 1994. J Immunol. 152(5):2157-62. PMID: 8133032.
Mason et al. 1992. Eur J Immunol. 22(10):2753-6. PMID: 1396979.
Ouchida et al. 2010. J Immunol. 185(1):294-301. PMID: 20519653.
The B29 and mb-1 polypeptides are differentially expressed during human B cell differentiation.
The structure of the mu/pseudo light chain complex on human pre-B cells is consistent with a function in signal transduction.
Add a reference
