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Anti-CD79a [HM47] recombinant antibody
RECENTLY UPDATED

Invented at University of Oxford

Info

Catalogue Number 154816
Antigen/Gene or Protein Targets
RECENTLY UPDATED
CD79a
Synonyms
RECENTLY UPDATED
B-cell antigen receptor complex-associated protein alpha chain; Ig-alpha; MB-1 membrane glycoprotein; Membrane-bound immunoglobulin-associated protein; Surface IgM-associated protein
Reactivity
RECENTLY UPDATED
Bovine, Chicken, Horse, Human, Guinea Pig, Mouse, Opossum, Pig, Primate, Rat and Rabbit
Relevance
RECENTLY UPDATED
The B cell Antigen receptor constitutes a disulphide linked heterodimer, consisting of CD79a / mb1 and CD79b / B29 polypeptides, non covalently associated with membrane bound immunoglobulins on B cells. CD79a first appears at pre B cell stage and persists until the plasma cell stage where it is found as an intracellular component. CD79a is found in B cell lymphomas, in B cell lines, the majority of acute leukemias of precursor B cell type and in some myelomas. The CD79a/b heterodimer interacts with at least one tyrosine kinase (Lyn). Induction of tyrosine kinase activity after antigen binding causes phosphorylation of the CD79a/b dimer, and also of other molecules, thereby initiating intracellular signaling. CD79a is widely used as an adjunct to CD20 for detecting normal and neoplastic B cells in tissues sections.
Host
RECENTLY UPDATED
Mouse
Immunogen
RECENTLY UPDATED
Synthetic peptide of 14 amino acids representing amino acids 202-216 of the human mb-1 cDNA sequence
Subclass
RECENTLY UPDATED
IgG1
Research Area
RECENTLY UPDATED
Adhesion, Cancer, Cell Type or Organelle Marker, Cell Signaling & Signal Transduction, Immunology, Stem Cell Biology

References

There are 8 reference entries for this reagent.

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References: 8 entries
RECENTLY UPDATED

Brouns et al. 1993. Eur J Immunol. 23(5):1088-97. PMID: 8477803.

Evidence for a direct physical interaction of membrane IgM, IgD, and IgG with the B29 gene product.

Lankester et al. 1994. J Immunol. 152(5):2157-62. PMID: 8133032.

Mason et al. 1991. J Immunol. 147(11):2474-82. PMID: 1747162.

The IgM-associated protein mb-1 as a marker of normal and neoplastic B cells.

The membrane IgM-associated heterodimer on human B cells is a newly defined B cell antigen that contains the protein product of the mb-1 gene.

The structure of the mu/pseudo light chain complex on human pre-B cells is consistent with a function in signal transduction.

van Noesel et al. 1991. J Immunol. 146(11):3881-8. PMID: 2033258.


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References: 8 entries
RECENTLY UPDATED

Brouns et al. 1993. Eur J Immunol. 23(5):1088-97. PMID: 8477803.

Evidence for a direct physical interaction of membrane IgM, IgD, and IgG with the B29 gene product.

Lankester et al. 1994. J Immunol. 152(5):2157-62. PMID: 8133032.

Mason et al. 1991. J Immunol. 147(11):2474-82. PMID: 1747162.

The IgM-associated protein mb-1 as a marker of normal and neoplastic B cells.

The membrane IgM-associated heterodimer on human B cells is a newly defined B cell antigen that contains the protein product of the mb-1 gene.

The structure of the mu/pseudo light chain complex on human pre-B cells is consistent with a function in signal transduction.

van Noesel et al. 1991. J Immunol. 146(11):3881-8. PMID: 2033258.


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Inventor Information

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