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Anti-CD11a (Integrin Subunit Alpha L ) [SPVL7] monoclonal antibody
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Info

Catalogue Number 154792
Applications FACS IP
Antigen/Gene or Protein Targets CD11a
Synonyms ITGAL; LFA-1A
Reactivity Human
Relevance ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signalling.
Host Mouse
Immunogen Immunization of BALB/c mice with cells of the T4+T8- cytotoxic T lymphocyte clone HG-38
Subclass IgG1
Molecular Weight (kDa) 126
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions IMDM + 10% FBS ulta low IgG, 37 ⁰C 5% CO2
Strain Balb/c
Notes Fusion partners: derived by fusion of Sp2/0 mouse myeloma cells with splenocytes from BALB/c mouse.
Antibody recognizes the human equivalents of the LFA-1 antigen.
Research Area Adhesion, Cell Signaling & Signal Transduction

References

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References: 1 entry

Keizer et al. 1985. Eur J Immunol. 15(11):1142-8. PMID: 2933266.


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References: 1 entry

Keizer et al. 1985. Eur J Immunol. 15(11):1142-8. PMID: 2933266.


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