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Anti-CD51 (Victronectin receptor ) [NKIM7] monoclonal antibody
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Info

Catalogue Number 154784
Applications FACS IHC IP
Antigen/Gene or Protein Targets CD51
Synonyms ITGAV; Integrin Subunit Alpha V
Reactivity Human
Relevance ITGAV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction
Host Mouse
Immunogen Cultured melanoma cells derived from a human melanoma metastasis.
Subclass IgG1
Molecular Weight (kDa) 116
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions RPMI +10% FBS ultra low IgG, 37 ⁰C 5% CO2
Strain Balb/c
Notes Fusion partners: SP2/0 x spleen cells origin BALB/C.
The antibody reacts strongly with melanoma cells derived from cell lines and short term cultures and melanoma cells in frozen tissue sections.
Research Area Adhesion, Cell Structure and Motility, Immunology

References

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References: 1 entry

de Vries et al. 1986. Int J Cancer. 38(4):465-73. PMID: 2428758.


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References: 1 entry

de Vries et al. 1986. Int J Cancer. 38(4):465-73. PMID: 2428758.


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