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Anti-Melanoma cells [NKIM6] monoclonal Antibody
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Catalogue Number 154783
Applications N/A
Antigen/Gene or Protein Targets Melanoma cells
Reactivity Human
Relevance Melanoma, also known as malignant melanoma, is a type of cancer that develops from the pigment-containing cells known as melanocytes. In women, they most commonly occur on the legs, while in men they are most common on the back. Sometimes they develop from a mole with changes such as an increase in size, irregular edges, change in colour, itchiness, or skin breakdown.
Host Mouse
Immunogen A mouse was immunized with cultured melanoma cells derived from a human melanoma metastasis.
Myeloma Used Sp2/0-Ag14
Strain Balb/c
Notes Fusion partners: SP2/0 x spleen cells origin BALB/C.
This antibody recognizes a high molecular weight proteoglycan with a molecular weight > 450 kD (chondroitin sulfate) and 250 kD (core protein). The antibody reacts strongly with melanoma cells derived from cell lines and short term cultures and reacts preferentially with melanoma cells in frozen tissue sections. The antibody can also be used to detect melanoma lesions in vivo.
Research Area Cancer

References

There are 2 reference entries for this reagent.

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References: 2 entries

de Vries et al. 1986. Int J Cancer. 38(4):465-73. PMID: 2428758.

Buraggi et al. 1985. Cancer Res. 45(7):3378-87. PMID: 4005860.


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References: 2 entries

de Vries et al. 1986. Int J Cancer. 38(4):465-73. PMID: 2428758.

Buraggi et al. 1985. Cancer Res. 45(7):3378-87. PMID: 4005860.


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