Anti-Melanoma Associated Antigen 100 (Gp100) [Beteb] monoclonal antibody
Invented at Netherlands Cancer Institute
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- Inventor Info
Info
| Catalogue Number | 154782 |
| Applications | IHC |
| Antigen/Gene or Protein Targets | Melanoma Associated Antigen 100 |
| Reactivity | Human |
| Relevance | Gp100 plays a central role in the biogenesis of melanosomes. Involved in the maturation of melanosomes from stage I to II. The transition from stage I melanosomes to stage II melanosomes involves an elongation of the vesicle, and the appearance within of distinct fibrillar structures. Release of the soluble form, ME20-S, could protect tumour cells from antibody mediated immunity. |
| Host | Mouse |
| Immunogen | Purified membranes of a human melanoma lymph node metastasis |
| Subclass | IgG2b |
| Molecular Weight (kDa) | 70 |
| Myeloma Used | Sp2/0-Ag14 |
| Recommended Growing Conditions | IMDM + 1% ZAP, 37 ⁰C 5% CO2 |
| Strain | Balb/c |
| Notes |
Fusion partners: SP2/0 x spleen cells origin BALB/C. The antibody reacts with melanomas, clear cell sarcomas (melanoma of soft tissue), nevocellular nevi, and normal melanocytes. Except for one case of non-Hodgkin's lymphoma in which macrophages were positive, no reactions with other tumours or tissues have been observed. |
| Research Area | Cancer |
