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Anti-Melanoma Associated Antigen 100 (Gp100) [Beteb] monoclonal antibody
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Catalogue Number 154782
Applications IHC
Antigen/Gene or Protein Targets Melanoma Associated Antigen 100
Reactivity Human
Relevance Gp100 plays a central role in the biogenesis of melanosomes. Involved in the maturation of melanosomes from stage I to II. The transition from stage I melanosomes to stage II melanosomes involves an elongation of the vesicle, and the appearance within of distinct fibrillar structures. Release of the soluble form, ME20-S, could protect tumour cells from antibody mediated immunity.
Host Mouse
Immunogen Purified membranes of a human melanoma lymph node metastasis
Subclass IgG2b
Molecular Weight (kDa) 70
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions IMDM + 1% ZAP, 37 ⁰C 5% CO2
Strain Balb/c
Notes Fusion partners: SP2/0 x spleen cells origin BALB/C.
The antibody reacts with melanomas, clear cell sarcomas (melanoma of soft tissue), nevocellular nevi, and normal melanocytes. Except for one case of non-Hodgkin's lymphoma in which macrophages were positive, no reactions with other tumours or tissues have been observed.
Research Area Cancer

References

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References: 1 entry

Vennegoor et al. 1988. Am J Pathol. 130(1):179-92. PMID: 3276209.


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References: 1 entry

Vennegoor et al. 1988. Am J Pathol. 130(1):179-92. PMID: 3276209.


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