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Catalogue Number
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154774 |
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Applications
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IHC
IP
WB
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Antigen/Gene or Protein Targets
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MHC class I
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Reactivity
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Human
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Relevance
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MHC class I molecules are one of two primary classes of major histocompatibility complex (MHC) molecules (the other being MHC class II) and are found on the cell surface of all nucleated cells in the bodies of jawed vertebrates. They also occur on platelets, but not on red blood cells. Their function is to display peptide fragments of proteins from within the cell to cytotoxic T cells; this will trigger an immediate response from the immune system against a particular non-self antigen displayed with the help of an MHC class I protein. Because MHC class I molecules present peptides derived from cytosolic proteins, the pathway of MHC class I presentation is often called cytosolic or endogenous pathway.
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Host
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Mouse
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Immunogen
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Immunized with HLA-B7 and -B40 heavy chains
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Subclass
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IgG1
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Myeloma Used
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Sp2/0-Ag14
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Recommended Growing Conditions
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IMDM + 10% FBS ulta low IgG, 37 ⁰C 5% CO2
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Strain
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Balb/c
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Notes
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Fusion partners: fusion of SP2/0-Ag14 mouse myeloma cells with spleen cells from BALB/c mice.
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Research Area
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Cell Signaling & Signal Transduction, Immunology
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