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Catalogue Number
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154751 |
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Applications
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ELISA
FACS
IHC
IF
IP
WB
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Antigen/Gene or Protein Targets
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CD104
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Synonyms
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ITGB4; GP150
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Reactivity
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Human
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Relevance
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The ITGB4 gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia.
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Host
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Mouse
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Immunogen
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The full length CD104 protein
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Subclass
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IgG2a
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Molecular Weight (kDa)
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202
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Recommended Growing Conditions
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DMEM + 10% FBS ultra low IgG, 37 ⁰C 5% CO2
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Notes
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Binds specifically to integrin β4 chain(CD104) or β4 integrin, that associates with integrin α6 (CD49f) forms α6/β4 (CD49f/CD104) heterodimer. CD104 is expressed on epithelial cells (especially on the proliferative basal layer epithelial cells in skin), endothelial cells, Schwann cells, certain tumour cells and a subset of pre-T cells.
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Research Area
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Adhesion, Cancer, Cell Signaling & Signal Transduction
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