Anti-TCR γδ [11F2] monoclonal Antibody
Invented at Netherlands Cancer Institute
- Datasheet
- References (3)
- Inventor Info
Info
| Catalogue Number | 154750 |
| Applications | ELISA FACS IHC IP |
| Antigen/Gene or Protein Targets | TCR γδ |
| Reactivity | Human |
| Relevance | The T-cell receptor (TCR) is a molecule found on the surface of T cells, or T lymphocytes, that is responsible for recognizing fragments of antigen as peptides bound to major histocompatibility complex (MHC) molecules. The TCR is composed of two different protein chains (that is, it is a heterodimer). In humans, in 95% of T cells the TCR consists of an alpha (α) chain and a beta (β) chain (encoded by TRA and TRB, respectively), whereas in 5% of T cells the TCR consists of gamma and delta (γ/δ) chains (encoded by TRG and TRD, respectively). This ratio changes during ontogeny and in diseased states such as leukaemia. |
| Host | Mouse |
| Immunogen | Purified native TCRg/d |
| Subclass | IgG1 |
| Myeloma Used | Sp2/0-Ag14 |
| Recommended Growing Conditions | IMDM + 10% FBS ulta low IgG, 37 ⁰C 5% CO2 |
| Strain | Balb/c |
| Notes | Fusion partners: SP2/0 x spleen cells BALB/c mouse |
| Research Area | Cell Signaling & Signal Transduction, Immunology |
References: 3 entries
Vroom et al. 1991. J Clin Pathol. 44(12):1012-7. PMID: 1838746.
Bos et al. 1990. J Invest Dermatol. 94(1):37-42. PMID: 1688597.
Borst et al. 1988. J Exp Med. 167(5):1625-44. PMID: 2966845.
Add a reference
References: 3 entries
Vroom et al. 1991. J Clin Pathol. 44(12):1012-7. PMID: 1838746.
Bos et al. 1990. J Invest Dermatol. 94(1):37-42. PMID: 1688597.
Borst et al. 1988. J Exp Med. 167(5):1625-44. PMID: 2966845.
Add a reference
