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Anti-TCR γδ [11F2] monoclonal Antibody
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Catalogue Number 154750
Applications ELISA FACS IHC IP
Antigen/Gene or Protein Targets TCR γδ
Reactivity Human
Relevance The T-cell receptor (TCR) is a molecule found on the surface of T cells, or T lymphocytes, that is responsible for recognizing fragments of antigen as peptides bound to major histocompatibility complex (MHC) molecules. The TCR is composed of two different protein chains (that is, it is a heterodimer). In humans, in 95% of T cells the TCR consists of an alpha (α) chain and a beta (β) chain (encoded by TRA and TRB, respectively), whereas in 5% of T cells the TCR consists of gamma and delta (γ/δ) chains (encoded by TRG and TRD, respectively). This ratio changes during ontogeny and in diseased states such as leukaemia.
Host Mouse
Immunogen Purified native TCRg/d
Subclass IgG1
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions IMDM + 10% FBS ulta low IgG, 37 ⁰C 5% CO2
Strain Balb/c
Notes Fusion partners: SP2/0 x spleen cells BALB/c mouse
Research Area Cell Signaling & Signal Transduction, Immunology

References

There are 3 reference entries for this reagent.

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References: 3 entries

Vroom et al. 1991. J Clin Pathol. 44(12):1012-7. PMID: 1838746.

Bos et al. 1990. J Invest Dermatol. 94(1):37-42. PMID: 1688597.

Borst et al. 1988. J Exp Med. 167(5):1625-44. PMID: 2966845.


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References: 3 entries

Vroom et al. 1991. J Clin Pathol. 44(12):1012-7. PMID: 1838746.

Bos et al. 1990. J Invest Dermatol. 94(1):37-42. PMID: 1688597.

Borst et al. 1988. J Exp Med. 167(5):1625-44. PMID: 2966845.


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