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Anti- CD51 (Integrin Subunit Alpha V) [NKIM9] monoclonal antibody
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Invented by Prof Arnoud Sonnenberg at Netherlands Cancer Institute

Info

Catalogue Number 154749
Applications FACS IHC IF IP
Antigen/Gene or Protein Targets CD51
Synonyms ITGAV; Vitronectin Receptor
Reactivity Human
Relevance ITGAV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction
Host Mouse
Immunogen Cultured melanoma cells derived from a human melanoma metastasis.
Subclass IgG2a
Molecular Weight (kDa) 116
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions IMDM + 4% FBS ulta low IgG, 37 ⁰C 5% CO2
Strain Balb/c
Notes Fusion partners: SP2/0 mouse myeloma cells with spleen cells from a BALB/c mouse immunized with cultured melanoma cells derived from a human melanoma metastasis

The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors
Research Area Adhesion, Immunology

References

There are 1 reference entries for this reagent.

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References: 1 entry

Nesbitt et al. 1993. J Biol Chem. 268(22):16737-45. PMID: 8344953.


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References: 1 entry

Nesbitt et al. 1993. J Biol Chem. 268(22):16737-45. PMID: 8344953.


Add a reference