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Catalogue Number
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154747 |
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Applications
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IHC
WB
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Antigen/Gene or Protein Targets
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Integrin α3B and α6B
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Synonyms
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ITGA3; ITGA6
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Reactivity
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Human
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Relevance
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ITGA3 is an integrin alpha subunit. Together with beta-1 subunit, it makes up half of the α3β1 integrin duplex that plays a role in neural migration and corticogenesis, acted upon by such factors as netrin-1 and reelin.
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Host
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Mouse
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Immunogen
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A mouse was immunized with a synthetic peptide corresponding to a 32 amino acid stretch in the cytoplasmic domain of integrin á3B including an appending N-terminal cysteine coupled to keyhole limpet hemocyanin.
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Subclass
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IgG1
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Myeloma Used
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Sp2/0-Ag14
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Recommended Growing Conditions
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DMEM + 10% FBS ultra low IgG, 37 ⁰C 5% CO2
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Strain
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Balb/c
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Notes
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Fusion partners: SP2/0 mouse myeloma cells with spleen cells from a BALB/c mouse. PB36 recognizes the cytoplasmic domain of integrin subunits α3B and α6B. PB36 reacts with the basement membrane zone and endothelial cells in skin, tubuli in kidney and all vascular and capillary endothelia in brain and heart.
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Research Area
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Adhesion, Cell Signaling & Signal Transduction
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