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Anti-Cytokeratin 18 [DEK18] monoclonal Antibody
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Invented by Prof Arnoud Sonnenberg at Netherlands Cancer Institute

Info

Catalogue Number 154746
Applications FACS IHC IF IP WB
Antigen/Gene or Protein Targets Cytokeratin 18
Synonyms KRT18; Keratin 18
Reactivity Dog, Human and Feline
Relevance Cytokeratin 18 is a type I cytokeratin. It is, together with its filament partner keratin 8, perhaps the most commonly found products of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene
Host Mouse
Immunogen Cytoskeletal preperation extracted from humen epidermis
Subclass IgG1
Molecular Weight (kDa) 48
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions IMDM + 4% FBS ulta low IgG, 37 ⁰C 5% CO2
Strain Balb/c
Notes Fusion partners: SP2/0 myeloma x spleen cells origin BALB/C. This antibody reacts exclusively with cytokeratin18 is present in glandular epithelial cells of the digestive, respiratory, urogenital tracts, endocrine and exocrine cells and mesothelial cells, as well as adenocarcinomas originating from them.
Research Area Cancer, Cell Structure and Motility

References

There are 3 reference entries for this reagent.

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References: 3 entries

Glebov et al. 2006. Nat Cell Biol. 8(1):46-54. PMID: 16341206.

Bonfrer et al. 1994. Tumour Biol. 15(4):210-22. PMID: 7524130.

Vos et al. 1992. Zentralbl Veterinarmed A. 39(10):721-40. PMID: 1283472.


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References: 3 entries

Glebov et al. 2006. Nat Cell Biol. 8(1):46-54. PMID: 16341206.

Bonfrer et al. 1994. Tumour Biol. 15(4):210-22. PMID: 7524130.

Vos et al. 1992. Zentralbl Veterinarmed A. 39(10):721-40. PMID: 1283472.


Add a reference