Cancer Research Technology
Log in Register
Menu

Anti-Integrin α-6A [1A10] monoclonal Antibody
NEW

Invented by Prof Arnoud Sonnenberg at Netherlands Cancer Institute

Info

Catalogue Number 154740
Applications IHC WB
Antigen/Gene or Protein Targets Integrin α6A
Synonyms ITGA6; CD49F Antigen; VLA-6
Reactivity Human
Relevance The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Specific loss of this integrin chain in the intestinal epithelium, and thus of their hemidesmosomes, induces long-standing colitis and infiltrating adenocarcinomas.
Host Mouse
Immunogen A mouse was immunized with a synthetic peptide corresponding to the C terminal 28 amino acids of integrin α6A including an appending N-terminal cysteine (CKKDHYDATYHKAEIHAQPSDKERLTSDA) coupled to keyhole limpet hemocyanin.
Subclass IgG1
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions IMDM + 1% ZAP, 37 ⁰C 5% CO2
Strain Balb/c
Notes Fusion partners: SP2/0 mouse myeloma cells with spleen cells from a BALB/c mouse. Reacts exclusively with the cytoplasmic domain of non-phosphorylated integrin subunit α6A
Research Area Adhesion, Cell Signaling & Signal Transduction

References

There are 1 reference entries for this reagent.

View All References

References: 1 entry

Hogervorst et al. 1993. J Cell Biol. 121(1):179-91. PMID: 7681434.


Add a reference

References: 1 entry

Hogervorst et al. 1993. J Cell Biol. 121(1):179-91. PMID: 7681434.


Add a reference