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Catalogue Number
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154740 |
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Applications
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IHC
WB
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Antigen/Gene or Protein Targets
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Integrin α6A
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Synonyms
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ITGA6; CD49F Antigen; VLA-6
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Reactivity
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Human
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Relevance
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The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Specific loss of this integrin chain in the intestinal epithelium, and thus of their hemidesmosomes, induces long-standing colitis and infiltrating adenocarcinomas.
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Host
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Mouse
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Immunogen
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A mouse was immunized with a synthetic peptide corresponding to the C terminal 28 amino acids of integrin α6A including an appending N-terminal cysteine (CKKDHYDATYHKAEIHAQPSDKERLTSDA) coupled to keyhole limpet hemocyanin.
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Subclass
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IgG1
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Myeloma Used
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Sp2/0-Ag14
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Recommended Growing Conditions
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IMDM + 1% ZAP, 37 ⁰C 5% CO2
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Strain
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Balb/c
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Notes
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Fusion partners: SP2/0 mouse myeloma cells with spleen cells from a BALB/c mouse. Reacts exclusively with the cytoplasmic domain of non-phosphorylated integrin subunit α6A
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Research Area
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Adhesion, Cell Signaling & Signal Transduction
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