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Anti-CD49E (Integrin Alpha 5) [SAM1] monoclonal antibody
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Invented by Prof Arnoud Sonnenberg at Netherlands Cancer Institute

Info

Catalogue Number 154737
Applications FACS IHC IP
Antigen/Gene or Protein Targets CD49E
Synonyms ITGA5
Reactivity Human
Relevance The ITGA5 gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling
Host Mouse
Immunogen U 937 cells
Subclass IgG2b
Molecular Weight (kDa) 135
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions IMDM + 1% ZAP + 4% FBS ultra low IgG, 37 ⁰C 5% CO2
Strain Balb/c
Notes Fusion partners: SP2/0 x spleen cells origin BALB/C. This antibody recognizes a receptor for fibronectin: CD49e = VLA-5 protein from the integrin superfamily.
Research Area Adhesion, Cell Signaling & Signal Transduction

References

There are 2 reference entries for this reagent.

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References: 2 entries

Sopp et al. 1997. Vet Immunol Immunopathol. 56(1-2):11-25. PMID: 9220577.

te Velde et al. 1988. J Immunol. 140(5):1548-54. PMID: 3279117.


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References: 2 entries

Sopp et al. 1997. Vet Immunol Immunopathol. 56(1-2):11-25. PMID: 9220577.

te Velde et al. 1988. J Immunol. 140(5):1548-54. PMID: 3279117.


Add a reference