Anti-CD49E (Integrin Alpha 5) [SAM1] monoclonal antibody
Invented by Prof Arnoud Sonnenberg from Netherlands Cancer Institute
Invented at Netherlands Cancer Institute
- Datasheet
- References (2)
- Inventor Info
Info
| Catalogue Number | 154737 |
| Applications | FACS IHC IP |
| Antigen/Gene or Protein Targets | CD49E |
| Synonyms | ITGA5 |
| Reactivity | Human |
| Relevance | The ITGA5 gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling |
| Host | Mouse |
| Immunogen | U 937 cells |
| Subclass | IgG2b |
| Molecular Weight (kDa) | 135 |
| Myeloma Used | Sp2/0-Ag14 |
| Recommended Growing Conditions | IMDM + 1% ZAP + 4% FBS ultra low IgG, 37 ⁰C 5% CO2 |
| Strain | Balb/c |
| Notes | Fusion partners: SP2/0 x spleen cells origin BALB/C. This antibody recognizes a receptor for fibronectin: CD49e = VLA-5 protein from the integrin superfamily. |
| Research Area | Adhesion, Cell Signaling & Signal Transduction |
References: 2 entries
Sopp et al. 1997. Vet Immunol Immunopathol. 56(1-2):11-25. PMID: 9220577.
te Velde et al. 1988. J Immunol. 140(5):1548-54. PMID: 3279117.
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References: 2 entries
Sopp et al. 1997. Vet Immunol Immunopathol. 56(1-2):11-25. PMID: 9220577.
te Velde et al. 1988. J Immunol. 140(5):1548-54. PMID: 3279117.
Add a reference
