Anti-CD49F (Integrin Alpha 6) [GoH3] monoclonal antibody
Invented by Prof Arnoud Sonnenberg from Netherlands Cancer Institute
Invented at Netherlands Cancer Institute
- Datasheet
- References (4)
- Inventor Info
Info
| Catalogue Number | 154730 |
| Applications | FACS IHC IP |
| Antigen/Gene or Protein Targets | CD49F |
| Synonyms | ITGA6 |
| Reactivity | Dog, Human and Mouse |
| Relevance | The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Specific loss of this integrin chain in the intestinal epithelium, and thus of their hemidesmosomes, induces long-standing colitis and infiltrating adenocarcinomas. |
| Host | Rat |
| Immunogen | 1242-1255 of the C-terminus of the Human c-erbB-2/HER-2/neu protein. This sequence is identical in Rat neu |
| Subclass | IgG2a |
| Molecular Weight (kDa) | 126 |
| Myeloma Used | Sp2/0-Ag14 |
| Recommended Growing Conditions | IMDM + 1% ZAP, 37 ⁰C 5% CO2 |
| Strain | Balb/c |
| Notes | Directed against the Cdw49f-antigen, 120kDa, (GP Ic or VLA-6 alpha-chain), The monoclonal antibody reacts with platelets, megakaryocytes, T lymphocytes and common Acute Lymphoblastic Leukaemia cells (alpha-6 beta-1). In immunohistology the monoclonal antibody reacts with epithelial cells of a variety of tissues, peripheral nerves, microvascular endothelial cells, placenta cyto- and syncytotrophoblasts. Platelet VL-6 functions as a laminin receptor and platelet adhesion to laminin is inhibited by GoH3. GoH3 is a Rat monoclonal IgG2a antibody obtained by immunizing Sprague-Dawley Rats with Mouse (BALB/c) mammary tumour cells. |
| Research Area | Immunology |
References: 4 entries
Yoshino et al. 2000. Exp Anim. 49(2):97-110. PMID: 10889948.
Upgrading of flow cytometric analysis for absolute counts, cytokines and other antigenic molecules of cynomolgus monkeys (Macaca fascicularis) by using anti-human cross-reactive antibodies.
Europe PMC ID: 10889948
Galkowska et al. 1996. Vet Immunol Immunopathol. 53(3-4):329-34. PMID: 8969052.
Ticchioni et al. 1995. J Immunol. 154(3):1207-15. PMID: 7529794.
Add a reference
References: 4 entries
Yoshino et al. 2000. Exp Anim. 49(2):97-110. PMID: 10889948.
Upgrading of flow cytometric analysis for absolute counts, cytokines and other antigenic molecules of cynomolgus monkeys (Macaca fascicularis) by using anti-human cross-reactive antibodies.
Galkowska et al. 1996. Vet Immunol Immunopathol. 53(3-4):329-34. PMID: 8969052.
Ticchioni et al. 1995. J Immunol. 154(3):1207-15. PMID: 7529794.
Add a reference
