Anti-cErbB2/HER2 [3B5] monoclonal Antibody
Invented at Netherlands Cancer Institute
- Datasheet
- References (10)
- Inventor Info
Info
| Catalogue Number | 154729 |
| Applications | IHC IF IP WB |
| Antigen/Gene or Protein Targets | cErbB2/HER-2 |
| Synonyms | NEU |
| Reactivity | Human, Mouse and Rat |
| Relevance | HER2 is a member of the human epidermal growth factor receptor (HER/EGFR/ERBB) family. Amplification or over-expression of this oncogene has been shown to play an important role in the development and progression of certain aggressive types of breast cancer. In recent years the protein has become an important biomarker and target of therapy for approximately 30% of breast cancer patients |
| Host | Mouse |
| Immunogen | Mouse immunized with a synthetic peptide TAENPEYLGLDVPV corresponding to amino acid residues |
| Subclass | IgG1 |
| Molecular Weight (kDa) | 185 |
| Myeloma Used | Sp2/0-Ag14 |
| Recommended Growing Conditions | IMDM + 1% ZAP, 37 ⁰C 5% CO2 |
| Strain | Balb/c |
| Notes |
The Antibody reacts equally well with the wild as well as the mutant (oncogenic) form c-erbB-2 protein but preferentially recognizes the unphosphorylated form of c-erbB-2 protein. Derived by fusion of SP2/0 Mouse myeloma cells with spleen cells from a BALB/c |
| Research Area | Cancer, Cell Signaling & Signal Transduction |
References: 10 entries
Têtu et al. 1994. Cancer. 73(9):2359-65. PMID: 7909490.
Marks et al. 1994. Ann Surg. 219(4):332-41. PMID: 7909221.
van Leeuwen et al. 1990. Oncogene. 5(4):497-503. PMID: 1970152.
van de Vijver et al. 1988. N Engl J Med. 319(19):1239-45. PMID: 2903446.
Varley et al. 1987. Oncogene. 1(4):423-30. PMID: 3330785.
Di Fiore et al. 1987. Science. 237(4811):178-82. PMID: 2885917.
Slamon et al. 1987. Science. 235(4785):177-82. PMID: 3798106.
Yamamoto et al. 1986. Nature. 319(6050):230-4. PMID: 3003577.
Bargmann et al. 1986. Nature. 319(6050):226-30. PMID: 3945311.
Blick et al. 1984. Blood. 64(6):1234-9. PMID: 6208953.
Add a reference
References: 10 entries
Têtu et al. 1994. Cancer. 73(9):2359-65. PMID: 7909490.
Marks et al. 1994. Ann Surg. 219(4):332-41. PMID: 7909221.
van Leeuwen et al. 1990. Oncogene. 5(4):497-503. PMID: 1970152.
van de Vijver et al. 1988. N Engl J Med. 319(19):1239-45. PMID: 2903446.
Varley et al. 1987. Oncogene. 1(4):423-30. PMID: 3330785.
Di Fiore et al. 1987. Science. 237(4811):178-82. PMID: 2885917.
Slamon et al. 1987. Science. 235(4785):177-82. PMID: 3798106.
Yamamoto et al. 1986. Nature. 319(6050):230-4. PMID: 3003577.
Bargmann et al. 1986. Nature. 319(6050):226-30. PMID: 3945311.
Blick et al. 1984. Blood. 64(6):1234-9. PMID: 6208953.
Add a reference
