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Glycated HSA Rhodamine Boronic Acid small molecule (tool compound)

Invented by Marta P. Pereira Morais

Info

Catalogue Number 154474
Antigen/Gene or Protein Targets Advanced Glycation Endproducts (AGE); specifically Glycated Human Serum Albumin (HSA). Also binds ApoA-I protein.
Synonyms AGEs
Relevance Protein glycation, also known as non-enzymatic glycosylation, has been implicated in various disease states and is therefore an important biomarker for ageing and age-related chronic diseases such as diabetes, cardiovascular diseases, autoimmune diseases, cancer, and Alzheimer’s disease.

However their analysis is challenging due to the complexity of the protein-carbohydrate adducts. Fluorescent boronic acids like these enable the detection and identification of individual glycated proteins in complex samples through gel electrophoresis.
Research Area Neurobiology, Protein Degradation, Cardiovascular, Immunology
Notes This small molecule has been used to identify glycated proteins in human serum, insect hemolymph, and mouse brain homogenates.

References

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References: 1 entry

Pereira Morais et al. 2013. Sci Rep. 3:1437. PMID: 23531746.


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References: 1 entry

Pereira Morais et al. 2013. Sci Rep. 3:1437. PMID: 23531746.


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Inventor Information

Inventors

Marta P. Pereira Morais

Marta P. Pereira Morais

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