Glycated HSA Rhodamine Boronic Acid small molecule (tool compound)
Invented by Marta P. Pereira Morais
Invented at University Of Bath
- References (1)
- Inventor Info
|Antigen/Gene or Protein Targets||Advanced Glycation Endproducts (AGE); specifically Glycated Human Serum Albumin (HSA). Also binds ApoA-I protein.|
Protein glycation, also known as non-enzymatic glycosylation, has been implicated in various disease states and is therefore an important biomarker for ageing and age-related chronic diseases such as diabetes, cardiovascular diseases, autoimmune diseases, cancer, and Alzheimer’s disease.
However their analysis is challenging due to the complexity of the protein-carbohydrate adducts. Fluorescent boronic acids like these enable the detection and identification of individual glycated proteins in complex samples through gel electrophoresis.
|Research Area||Neurobiology, Protein Degradation, Cardiovascular, Immunology|
|Notes||This small molecule has been used to identify glycated proteins in human serum, insect hemolymph, and mouse brain homogenates.|
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Marta P. Pereira Morais