Anti-RTL1 [13C11] monoclonal antibody
Invented by Tsui-Han Loo
Invented at A*STAR Accelerate Technologies Pte Ltd
- Datasheet
- References (7)
- Inventor Info
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| Catalogue Number | 154472 |
| Applications | IF WB |
| Antigen/Gene or Protein Targets | RTL1 |
| Reactivity | Human and Mouse |
| Relevance |
RTL1 is an imprinted gene and is expressed from the paternal chromosome (Hagan et al., 2009; Lin et al., 2003). In human, excessive RTL1 expression and decreased RTL1 expression are relevant to upd(14)pat-like and upd(14)mat-like phenotypes, respectively(Ogata and Kagami, 2016). Upd(14)pat results in a unique phenotype characterized by facial abnormality, a small, bell-shaped thorax and abdominal wall defects, and upd(14)mat leads to pre- and postnatal growth failure and early onset of puberty. In sheep, excessive RTL1 expression is associated with muscle hypertrophy(Byrne et al., 2010). In mouse, null mice died in late fetal stages due to placenta defect (Ito et al., 2015; Sekita et al., 2008). Mis-regulation of Rtl1 is also associated with hepatocarcinogenesis (Riordan et al., 2013). |
| Host | Mouse |
| Immunogen | Human RTL1 C-terminus fragment |
| Immunogen UniProt ID | A6NKG5 |
| Positive Control | SH-SY5Y cell |
| Subclass | IgG2a lambda |
| Research Area | Gene Expression, Genetic Studies Tools |
References: 7 entries
Ogata et al. 2016. J Hum Genet. 61(2):87-94. PMID: 26377239.
Ito et al. 2015. Development. 142(14):2425-30. PMID: 26138477.
Riordan et al. 2013. PLoS Genet. 9(4):e1003441. PMID: 23593033.
Byrne et al. 2010. PLoS One. 5(1):e8638. PMID: 20072617.
Hagan et al. 2009. PLoS One. 4(2):e4352. PMID: 19194500.
Sekita et al. 2008. Nat Genet. 40(2):243-8. PMID: 18176565.
Lin et al. 2003. Nat Genet. 35(1):97-102. PMID: 12937418.
Add a reference
References: 7 entries
Ogata et al. 2016. J Hum Genet. 61(2):87-94. PMID: 26377239.
Ito et al. 2015. Development. 142(14):2425-30. PMID: 26138477.
Riordan et al. 2013. PLoS Genet. 9(4):e1003441. PMID: 23593033.
Byrne et al. 2010. PLoS One. 5(1):e8638. PMID: 20072617.
Hagan et al. 2009. PLoS One. 4(2):e4352. PMID: 19194500.
Sekita et al. 2008. Nat Genet. 40(2):243-8. PMID: 18176565.
Lin et al. 2003. Nat Genet. 35(1):97-102. PMID: 12937418.
Add a reference
Inventor Information
Inventors
|
Tsui-Han Loo |
