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Anti-RTL1 [13C11] monoclonal antibody
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Invented by Tsui-Han Loo

Info

Catalogue Number 154472
Applications IF WB
Antigen/Gene or Protein Targets RTL1
Reactivity Human and Mouse
Relevance RTL1 is an imprinted gene and is expressed from the paternal chromosome (Hagan et al., 2009; Lin et al., 2003).

In human, excessive RTL1 expression and decreased RTL1 expression are relevant to upd(14)pat-like and upd(14)mat-like phenotypes, respectively(Ogata and Kagami, 2016). Upd(14)pat results in a unique phenotype characterized by facial abnormality, a small, bell-shaped thorax and abdominal wall defects, and upd(14)mat leads to pre- and postnatal growth failure and early onset of puberty.

In sheep, excessive RTL1 expression is associated with muscle hypertrophy(Byrne et al., 2010). In mouse, null mice died in late fetal stages due to placenta defect (Ito et al., 2015; Sekita et al., 2008). Mis-regulation of Rtl1 is also associated with hepatocarcinogenesis (Riordan et al., 2013).
Host Mouse
Immunogen Human RTL1 C-terminus fragment
Immunogen UniProt ID A6NKG5
Positive Control SH-SY5Y cell
Subclass IgG2a lambda
Research Area Gene Expression, Genetic Studies Tools

References

There are 7 reference entries for this reagent.

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References: 7 entries

Ogata et al. 2016. J Hum Genet. 61(2):87-94. PMID: 26377239.

Ito et al. 2015. Development. 142(14):2425-30. PMID: 26138477.

Riordan et al. 2013. PLoS Genet. 9(4):e1003441. PMID: 23593033.

Byrne et al. 2010. PLoS One. 5(1):e8638. PMID: 20072617.

Hagan et al. 2009. PLoS One. 4(2):e4352. PMID: 19194500.

Sekita et al. 2008. Nat Genet. 40(2):243-8. PMID: 18176565.

Lin et al. 2003. Nat Genet. 35(1):97-102. PMID: 12937418.


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References: 7 entries

Ogata et al. 2016. J Hum Genet. 61(2):87-94. PMID: 26377239.

Ito et al. 2015. Development. 142(14):2425-30. PMID: 26138477.

Riordan et al. 2013. PLoS Genet. 9(4):e1003441. PMID: 23593033.

Byrne et al. 2010. PLoS One. 5(1):e8638. PMID: 20072617.

Hagan et al. 2009. PLoS One. 4(2):e4352. PMID: 19194500.

Sekita et al. 2008. Nat Genet. 40(2):243-8. PMID: 18176565.

Lin et al. 2003. Nat Genet. 35(1):97-102. PMID: 12937418.


Add a reference

Inventor Information