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16E6/E7-HSK cell line

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Catalogue Number 154462
Antigen/Gene or Protein Targets Used as an immortal adult human skin keratinocyte line for pathogenesis and inflammation studies
Parental Line Keratinocytes isolated from punch biopsies of the skin from the buttocks
Host Human
Disease Keywords Cancer
Relevance Expresses skin cell markers; proinflammatory
Production Details Cells were transduced with HPV-16 E6/E7 LXSN replication defective retrovirus and selected in G418
Conditional No
Research Area Cancer, Microbiology, Virology
Growth/Phenotype Keywords Upregulation of telomerase and greatly extended lifespan (greater than 5 times the lifespan of untransduced keratinocytes) with no apparent crisis or slow down in growth. Despite upregulation of telomerase, E6/E7 transduced keratinocytes exhibited significant telomere shortening with passaging in culture
Recommended Growing Conditions G418 selection.

References

There are 2 reference entries for this reagent.

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References: 2 entries

Gourronc et al. 2010. Exp Dermatol. 19(3):279-88. PMID: 19558498.

Proliferative defects in dyskeratosis congenita skin keratinocytes are corrected by expression of the telomerase reverse transcriptase, TERT, or by activation of endogenous telomerase through expression of papillomavirus E6/E7 or the telomerase RNA compon

Europe PMC ID: 19558498


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References: 2 entries

Gourronc et al. 2010. Exp Dermatol. 19(3):279-88. PMID: 19558498.

Proliferative defects in dyskeratosis congenita skin keratinocytes are corrected by expression of the telomerase reverse transcriptase, TERT, or by activation of endogenous telomerase through expression of papillomavirus E6/E7 or the telomerase RNA compon


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